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GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. De plus, nous expédions rho GTPase Activating Protein 44 Anticorps (33) et beaucoup plus de produits pour cette protéine.
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Rho GTPase activating protein 44 (ARHGAP44) expression is lower in lung carcinoma compared with normal tissues. The GTP hydrolysis activity on cell division cycle 42 (Cdc42) and the expression level of ARHGAP44 are negatively correlated with cell migration and invasion.
RICH2 is implicated in viremic control of HIV-1 in black South African individuals.
Besides the already known chromosome 6 associations, the analysis of low-frequency single nucleotide polymorphisms brought up a new association in the RICH2 gene for progression to AIDS.
Knocking down expression of RICH 2 causes loss of the apical actin network and apical microvilli, an increase in actin bundles at the basal surface, and a reduction in cell height. (RICH 2 protein)
Demonstrates that the RhoGAP domains of RICH-1 and RICH-2 can catalyze GTP hydrolysis of both Rac1 and Cdc42, but not of RhoA.
RICH2 knockout animals display a selective and highly significant fear of novel objects and increased stereotypic behavior as well as impairment of motor learning.
These results suggested that Rich2 controls dendritic spine morphogenesis and function via inhibition of Rac1.
Knock-down of Rich2 or disruption of Rich2-Shank3 complex, inhibits dendritic spine enlargement.
Shows that the RhoGAP domain of the human RICH2 ortholog can catalyze GTP hydrolysis of both Rac1 and Cdc42, but not of RhoA.
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1.
Rho-type GTPase-activating protein RICH2
, Rho GTPase activating protein 44
, RhoGAP interacting with CIP4 homologs protein 2
, rho GTPase-activating protein 44
, rho GTPase-activating protein RICH2
, Rho GTPase-activating protein RICH2