serine Palmitoyltransferase, Long Chain Base Subunit 2 Protéines (SPTLC2)

SPTLC2 encodes a long chain base subunit of serine palmitoyltransferase. De plus, nous expédions serine Palmitoyltransferase, Long Chain Base Subunit 2 Anticorps (73) et serine Palmitoyltransferase, Long Chain Base Subunit 2 Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SPTLC2 9517 O15270
SPTLC2 20773 P97363
Rat SPTLC2 SPTLC2 366697  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$4,649.05
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Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$6,616.87
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Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
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Escherichia coli (E. coli) Souris T7 tag,His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
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SPTLC2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine) ,
,

Plus protéines pour serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) partenaires d'interaction

Human serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) interaction partners

  1. 2 families had late-onset autosomal dominant HSAN1C caused by a new variant in SPTLC2, c.547C>T, p.(Arg183Trp). The variant changed a conserved amino acid.

  2. The activities of the hLCB2a mutants were measured in the presence of ssSPTa and ssSPTb and was found that all decrease enzyme activity.

  3. Mutations in SPTLC2 are associated with increased deoxySL formation causing hereditary sensory and autonomic neuropathy type 1 (HSANI) in a familial study.

  4. Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

  5. results suggest that SPTLC2 mutations are not a common cause for genetic sensory neuropathies.

  6. Results suggest that functional serine palmitoyltransferase is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1 (Montrer SPTLC1 Protéines), SPTLC2 and SPTLC3 (Montrer SPTLC3 Protéines)) with a molecular mass of 480 kDa.

  7. discovery of 2 proteins, ssSPTa and ssSPTb, which each interacts with both hLCB1 (Montrer SPTLC1 Protéines) and hLCB2, suggesting that there are 4 distinct human SPT (Montrer AGXT Protéines) isozymes.

Mouse (Murine) serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) interaction partners

  1. The expression of SPT2 was stronger in vascular smooth muscle cells and neointima of carotid arteries from knock-out mice compared to wild-type.

  2. Data suggest that overexpression of serine palmitoyltransferase (Sptlc1 (Montrer SPTLC1 Protéines) and Sptlc2, serine palmitoyltransferase long chain base subunit 1 (Montrer SPTLC1 Protéines)/2) to elevate de novo sphingolipid biosynthesis induces autophagy in the liver.

  3. SPTLC2 knockout mice showed decreased ceramide levels in the epidermis, which impaired water-holding capacity and barrier function.

  4. Ldlr (Montrer LDLR Protéines) gene knockout mice with myeloid cell-specific Sptlc2 haploinsufficiency exhibited significantly less atherosclerosis than controls.

  5. Data show that LCAT (Montrer LCAT Protéines) activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2)+/- and sphingomyelin synthase 2 (Sms2 (Montrer SGMS2 Protéines))-/- mice, but markedly lower in ApoE (Montrer APOE Protéines)-/- and Ldlr (Montrer LDLR Protéines)-/- mice.

  6. results suggest that Sptlc2-mediated de novo ceramide synthesis is an essential source of C18 (Montrer BBS9 Protéines):0 and very long chain, but not of shorter chain, ceramides in the heart

  7. Inflammatory response elicited by lipopolysaccharide increases serine palmitoyltransferase activity via upregulation of Sptlc2 in macrophages.

  8. Deficiency of Sptlc2 induces necrotic lesions in gastrointestinal cells followed by atrophic change of the tissue in short term.

  9. Both Sptlc1 (Montrer SPTLC1 Protéines) and Sptlc2 interactions are necessary for Serine palmitoyl-CoA transferase (SPT (Montrer AGXT Protéines)) activity in vivo and SPT (Montrer AGXT Protéines) activity directly influences plasma sphingolipid levels

  10. The expression and activities of SPT (Montrer AGXT Protéines) in mouse liver increased significantly following fumonisin B1 treatment.

Profil protéine serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2)

Profil protéine

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.

Gene names and symbols associated with SPTLC2

  • serine palmitoyltransferase long chain base subunit 2 (SPTLC2)
  • serine palmitoyltransferase 2 (LOC100446763)
  • serine palmitoyltransferase long chain base subunit 2 (sptlc2)
  • serine palmitoyltransferase, long chain base subunit 2 S homeolog (sptlc2.S)
  • serine palmitoyltransferase, long chain base subunit 2a (sptlc2a)
  • serine palmitoyltransferase, long chain base subunit 2 (Sptlc2)
  • demilune cell and parotid protein 2 (Dcpp2)
  • serine palmitoyltransferase long chain base subunit 2 (Sptlc2)
  • serine palmitoyltransferase long chain base subunit 3 (SPTLC3)
  • AI173915 Protéine
  • Dcpp-2 Protéine
  • EG630537 Protéine
  • hLCB2a Protéine
  • HSN1C Protéine
  • LCB2 Protéine
  • LCB2a Protéine
  • mKIAA0526 Protéine
  • NSAN1C Protéine
  • Pomt2 Protéine
  • SPT-2 Protéine
  • SPT2 Protéine
  • SPTLC2 Protéine
  • zgc:110661 Protéine

Protein level used designations for SPTLC2

LCB 2 , SPT 2 , long chain base biosynthesis protein 2a , serine palmitoyltransferase 2 , serine palmitoyltransferase, subunit II , serine-palmitoyl-CoA transferase 2 , serine palmitoyltransferase, long chain base subunit 2 , serine palmitoyltransferase 2-like , LCB2a , long chain base biosynthesis protein 2 , protein-O-mannosyltransferase 2 , sublingual parotid tongue-2 salivary protein , Long chain base biosynthesis protein 2 , Long chain base biosynthesis protein 2a , Serine-palmitoyl-CoA transferase 2 , serine palmitoyltransferase 3

GENE ID SPECIES
9517 Homo sapiens
100158010 Sus scrofa
100446763 Pongo abelii
100464437 Ailuropoda melanoleuca
100566142 Anolis carolinensis
100601824 Nomascus leucogenys
423379 Gallus gallus
444190 Xenopus laevis
480403 Canis lupus familiaris
537972 Bos taurus
553646 Danio rerio
100059392 Equus caballus
20773 Mus musculus
366697 Rattus norvegicus
630537 Mus musculus
100689415 Cricetulus griseus
101115373 Ovis aries
100719612 Cavia porcellus
100336940 Bos taurus
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