anti-serine/arginine-Rich Splicing Factor 2 (SRSF2) Anticorps

The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. De plus, nous expédions SRSF2 Kits (17) et SRSF2 Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SRSF2 6427 Q01130
SRSF2 20382 Q62093
SRSF2 494445 Q6PDU1
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Top anti-SRSF2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 35 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-SFRS2 AntibodyTitration: 1.0 µg/mL  Positive Control: Hela Whole Cell  SRSF2 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Amphibien Souris Inconjugué ELISA, EM, ICC, IF, IP, WB Immunocytochemistry/Immunofluorescence: SC35 Antibody (SC-35) [ABIN151301] - HS-68 cells were fixed and permeabilized with 4% Paraformaldehyde and 0.5% Triton X-100. Fixed cells were stained with Mouse Anti-Splicing Factor Clone: SC-35 diluted to 1:2,000. The antibody was developed using Goat Anti-Mouse IgG, FITC-conjugate. Western Blot: SC35 Antibody (SC-35) [ABIN151301] - SC-35 recombinant protein (3 ug) was separated on SDS-PAGE and probed with Mouse Anti-Splicing Factor SC-35 Clone: SC-35. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. Lanes 1. Antibody dilution 1:100; 2. Antibody dilution 1:250; 3. Antibody dilution 1:500; 4. Antibody dilution 1:1,000 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$418.10
Détails
Humain Lapin Inconjugué WB Western blot analysis of SFRS2 Antibody (Center) (ABIN650729) in mouse stomach tissue lysates (35 µg/lane). SFRS2 (arrow) was detected using the purified polyclonal antibody. 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of anti-SFRS2 Antibody (N-term) (ABIN389301) in K562 cell line lysates (35 µg/lane).SFRS2(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SFRS2 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of SFRS2 Antibody (Center) in mouse stomach tissue lysates (35ug/lane). SFRS2 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p) Immunohistochemistry: SC35 Antibody [NBP2-47290] - Analysis of human Analysis of human skin tissue. Shows nuclear positivity. Immunocytochemistry/Immunofluorescence: SC35 Antibody [NBP2-47290] - Analysis of human cell line HEK 293 shows positivity in nucleus & cytoplasm. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$494.38
Détails
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Connectez-vous pour afficher 13 to 16 Days
$350.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of SFRS2 Antibody in mouse stomach tissue lysates (35ug/lane) 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué WB Western Blot: SC35 Antibody [NBP1-79886] - Hela Cell Lysate at a concentration of 1ug/ml in 12%gel 100 μL Connectez-vous pour afficher 8 to 11 Days
$488.73
Détails

anti-SRSF2 Anticorps mieux référencés

  1. Amphibian Monoclonal SRSF2 Primary Antibody pour ELISA, EM - ABIN151301 : Nie, Hampton, Fu, Liu, Findlay, Salamonsen: A potential molecular mechanism for regulating pre-mRNA splicing of implantation-related genes through unique uterine expression of splicing factor SC35 in women and rhesus monkeys. dans Reproduction (Cambridge, England) 2002 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal SRSF2 Primary Antibody pour ICC, IF - ABIN4352137 : Guantes, Rastrojo, Neves, Lima, Aguado, Iborra: Global variability in gene expression and alternative splicing is modulated by mitochondrial content. dans Genome research 2015 (PubMed)

Plus d’anticorps contre SRSF2 partenaires d’interaction

Human serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. Mycobacterium tuberculosis H37Rv infection regulates alternative splicing in host macrophages: SRSF2 and SRSF3 were found significantly down-regulated.

  2. SIRT1 interacts with and deacetylates SC35, and inhibits SC35-promoted tau exon 10 inclusion. Substituting K52 residue of SC35 by arginine impairs the role of SC35 in tau exon 10 inclusion.

  3. mutations in myelodysplasia patients preferentially affect splicing at 3' splice sites rather than at 5' splice sites

  4. SRSF2 mutations were significantly related to the shorter OS in patients with myelodysplastic syndromes which may consider as an adverse prognostic risk factor. Whereas, analysis did not show any prognostic effect on overall-survival of chronic myelomonocytic leukemia patients with SRSF2 mutations.

  5. SRSF2 is highly expressed in hepatocellular carcinoma and its expression increases with the degree of tumor differentiation and TNM staging. It is related to lymph node metastasis and metastasis of tumor cells, and is positively related to serum alpha fetoprotein content, and affects the postoperative survival time of HCC patients.

  6. We found that SON and SC35 (also known as SRSF2) localize to the central region of the speckle, whereas MALAT1 and small nuclear (sn)RNAs are enriched at the speckle periphery.

  7. Through a serial mutagenesis, authors demonstrate that a 10 nt RNA sequence surrounding the branch-point (BP), is important for SRSF2-mediated inhibition of cassette exon inclusion through directly interacting with SRSF2.

  8. The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor genes in myelodysplastic syndromes (SF3B1, SRSF2 and U2AF1) are being identified, illuminating the molecular mechanisms underlying the disease. (Review)

  9. adverse prognostic impact of SRSF2 mutations on OS and AML transformation in patients with de novo MDS

  10. SRSF2 mutation is associated with chronic myelomonocytic leukemia.

  11. Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells.

  12. Mutation in SRSF2 gene is associated with Uveal Melanoma.

  13. Myelodysplastic syndrome -related P95 point mutants of SRSF2 lead to alternative splicing of CDC25C in a manner that is not dependent on the DNA damage response.

  14. Findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC.

  15. depletion of the splicing factor arginine-rich splicing factor 2 (SRSF2) leads to enhanced cytotoxicity of breast cancer cells by KM100

  16. Data suggest that RBM25 is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 = RNA binding motif protein 25; SRSF2 = serine- and arginine-rich splicing factor 2)

  17. mutations in the SRSF2/ASXL1/RUNX1 gene panel identified as significant prognostic markers in systemic mastocytosis

  18. It was found that the absence of mutations in the SRSF2, ASXL1, and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

  19. These findings provide insight into the functions of SRSF2 in HSV-1 replication and gene expression.

  20. SRSF2 mutations were identified in Chinese AML patients. Patients with SRSF2 mutations were older than those with wild-type. No differences in the sex, blood parameters, FAB subtypes, and karyotypes were seen between AML patients with and without SRSF2 mutations. SRSF2 mutation was not an independent prognostic factor in AML patients.

Mouse (Murine) serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. Mutant Srsf2 leads to a compromised Hematopoietic stem cell function by causing abnormal RNA splicing and expression, contributing to the deregulated hematopoiesis that recapitulates the Myelodysplastic syndromes phenotypes, possibly as a result of additional genetic and/or environmental insults.

  2. Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells.

  3. Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS and AML, in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival.

  4. Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors.

  5. Depletion of SRSF2 enhances reovirus replication and cytopathic effect, suggesting that T1L mu2 modulation of splicing benefits the virus.

  6. HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase.

  7. The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.

  8. SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis-splicing of key hematopoietic regulators

  9. Study reports that SRSF2 (also known as SC35, an SR-splicing factor) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.

  10. Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.

  11. Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing.

  12. This protein was more abundant in the nucleoplasm of mice fed genetically-modified soybeans than in control mice.

  13. Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.

  14. intranuclear distribution of SC35 is dependent on GSK-3

  15. These findings reveal the involvement of SC35 in specific pathways in regulating cell proliferation and genomic stability during mammalian organogenesis and suggest its potential function in tumorigenesis.

  16. splicing factor SC35 has an active role in transcriptional elongation

SRSF2 profil antigène

Profil protéine

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.

Gene names and symbols associated with SRSF2

  • serine and arginine rich splicing factor 2 (SRSF2) anticorps
  • serine/arginine-rich splicing factor 2 (Srsf2) anticorps
  • serine and arginine rich splicing factor 2 (Srsf2) anticorps
  • serine/arginine-rich splicing factor 2 L homeolog (srsf2.L) anticorps
  • D11Wsu175e anticorps
  • MRF-1 anticorps
  • pr264 anticorps
  • sc-35 anticorps
  • sc35 anticorps
  • sfrs2 anticorps
  • sfrs2a anticorps
  • Sfrs10 anticorps
  • srp30b anticorps

Protein level used designations for SRSF2

SR splicing factor 2 , splicing component, 35 kDa , splicing factor SC35 , splicing factor, arginine/serine-rich 2 , myelin regulatory factor 1 , putative myelin regulatory factor 1 , splicing factor Sc35 , splicing factor, arginine/serine-rich 2 (SC-35) , SC-35 , PR 264 protein , arginine/serine-rich2 splicing factor

GENE ID SPECIES
6427 Homo sapiens
20382 Mus musculus
494445 Rattus norvegicus
508312 Bos taurus
396195 Gallus gallus
768117 Sus scrofa
380435 Xenopus laevis
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