anti-serine/arginine-Rich Splicing Factor 3 (SRSF3) Anticorps

The protein encoded by SRSF3 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. De plus, nous expédions SRSF3 Kits (6) et SRSF3 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SRSF3 6428 P84103
SRSF3 20383 P84104
SRSF3 361814  
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Showing 10 out of 67 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-SFRS3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Transfected 293T 100 μL 2 to 3 Days
Humain Lapin Inconjugué WB 100 μg 4 to 6 Days
Humain Lapin Inconjugué ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using SRp20 Polyclonal Antibody. 100 μL Disponible
Humain Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of SRSF3 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of SRSF3 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
Humain Lapin Inconjugué IF, ELISA, WB Western blot analysis of extracts from HeLa/Jurkat cells, using SFRS3 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of MCF7 cells, using SFRS3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Humain Lapin Inconjugué EIA, WB Western blot analysis using SFRS3 Antibody (Center) Cat.-No AP53880PU-N in HepG2 cell line lysates (35ug/lane). This demonstrates the SFRS3 antibody detected the SFRS3 protein (arrow). 0.4 mL 6 to 8 Days
Poulet Lapin Inconjugué IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-SRSF3 / SFRS3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this pro ... 100 μL 11 to 14 Days
Humain Souris Inconjugué IF, ELISA, WB Immunofluorescence of monoclonal antibody to SFRS3 on HeLa cell. [antibody concentration 10 ug/ml] SFRS3 monoclonal antibody (M08), clone 2D2 Western Blot analysis of SFRS3 expression in HeLa . 100 μg 11 to 12 Days
Humain Lapin Inconjugué ELISA, IF, IHC, IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 11 to 14 Days
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western blot analysis of extracts from HeLa cells using SFRS3 antibody. ABIN6274307 staining HeLa cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. 100 μL 11 to 12 Days

anti-SRSF3 Anticorps mieux référencés

  1. Human Monoclonal SRSF3 Primary Antibody pour IF, ELISA - ABIN562839 : Garbes, Riessland, Hölker, Heller, Hauke, Tränkle, Coras, Blümcke, Hahnen, Wirth: LBH589 induces up to 10-fold SMN protein levels by several independent mechanisms and is effective even in cells from SMA patients non-responsive to valproate. dans Human molecular genetics 2009 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre SRSF3 partenaires d’interaction

Human serine/arginine-Rich Splicing Factor 3 (SRSF3) interaction partners

  1. SRSF3 inhibits the expression of p65 and FoxO1 and their downstream target gene BECN1, a key regulator of autophagy. Our results demonstrated that splicing factor SRSF3 is an autophagy suppressor.

  2. We define a molecular pathway through which SLU7 keeps in check the generation of truncated forms of the splicing factor SRSF3 (SRp20) (SRSF3-TR). Behaving as dominant negative, or by gain-of-function, SRSF3-TR impair the correct splicing and expression of the splicing regulator SRSF1 (ASF/SF2) and the crucial SCC protein sororin.

  3. The genotype distribution of rs2145048 in SFRS3 was different between cases and controls. After adjusting for age, age at menarche and menopausal status, the A allele of rs2145048 showed an inverse association with breast cancer risk in the additive model (adjusted OR=0.81, 95% CI=0.71-0.92, P=0.001, Bonferroni corrected P=0.016).

  4. The increased SRSF3 expression in cancer cells plays an important role in maintaining the steady status of ILF3 isoform-1 and isoform-2.

  5. The results suggest that the absence of a pseudo-RRM(RNA recognition motif) renders the single RRM-containing SRSF3 more susceptible to dephosphorylation by phosphatase.

  6. Mycobacterium tuberculosis H37Rv infection regulates alternative splicing in host macrophages: SRSF2 and SRSF3 were found significantly down-regulated.

  7. The silencing of SRSF3 in human colon cancer cells induced a marked growth inhibition in both in vitro and in vivo experiments and caused an increase in the PKM1/PKM2 ratio, thus resulting in a metabolic shift from glycolysis to oxidative phosphorylation.

  8. Results show that SRSF3 impairs the autoregulation mechanism of SRSF5 and promotes the overexpression of SRSF5 in oral squamous cell carcinoma.

  9. TDP43 alters most splicing events with splicing factor SRSF3 in triple-negative breast cancer.

  10. Loss of SRSF3 expression was significantly associated with poor survival and shorter disease-free survival, particularly in early stages, in colorectal cancer.

  11. Findings reveal the molecular mechanism of SRSF3 in pri-miRNA processing and support the previously proposed explanation for the highly conserved position of CNNC in SRSF3-enhanced pri-miRNA processing.

  12. High expression of SRSF3 is associated with oral squamous cell carcinoma.

  13. RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 signaling pathway.

  14. MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3 via NKIRAS2 axis in osteosarcoma cells.

  15. Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 and SRSF3 in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA.

  16. that SRSF3 controls the expression of the miR-132/212 cluster through regulating REST expression

  17. Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons controlled by SRF3.

  18. Introduction of point mutations in the SRSF3-binding site or knockdown of SRSF3 expression in cells reduces human papillomavirus 18 929;3434 splicing and E1;E4 production but activates other, minor 929;3465 and 929;3506 splicing. Knockdown of SRSF3 expression also enhances the expression of E2 and L1 mRNAs.

  19. data indicate that the Human Papillomavirus E2 protein links the viral replication cycle to epithelial differentiation via SRSF3, a key cellular regulator of high-risk (HR)-HPV gene expression

  20. Results suggested that SRSF3 is associated with the initiation and development of OSCC and may be a biomarker and therapeutic target of OSCC.

Mouse (Murine) serine/arginine-Rich Splicing Factor 3 (SRSF3) interaction partners

  1. SRSF3 binds to the core pluripotency transcription factor Nanog mRNA to facilitate its nucleo-cytoplasmic export independent of splicing. In the absence of SRSF3 binding, Nanog mRNA is sequestered in the nucleus and protein levels are severely downregulated.

  2. Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism.

  3. SRSF3 regulates the innate immune response in resident microglia.

  4. Data liver/mammary gland expressing Srsf3 siRNA displayed a suppressed level of Srsf3 protein, but not the mRNA.

  5. potential role in preventing hepatic carcinogenesis by regulating splicing to suppress fibrosis, mitogenic splicing, and epithelial to mesenchymal transition

  6. This study provides the first evidence for a SRSF3-driven genetic programme required for morphological and functional differentiation of hepatocytes that may have relevance for human liver disease and metabolic dysregulation.

  7. Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver

  8. SRSF3 and SRSF4 proteins bind to the 3' ends of the majority of intronless histone transcripts, implicating SRSF3 and SRSF4 in histone mRNA metabolism.

  9. Results suggest that increased SRp20 expression in tumor cells is a critical step for tumor initiation, progression, and maintenance.

  10. mRNA targets of SRp20 and SRp75 were identified in cycling and neurally induced P19 cells.

  11. Hippocampal mRNA expression of Srp20 is up-regulated only in males during contextual fear memory formation as a specific result of the context/tone-shock association. Changes in expression during LTM formation regulate alternative splicing.

SRSF3 profil antigène

Profil protéine

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene.

Gene names and symbols associated with SRSF3

  • serine and arginine rich splicing factor 3 (SRSF3) anticorps
  • serine/arginine-rich splicing factor 3 (Srsf3) anticorps
  • serine/arginine-rich splicing factor 3 S homeolog (srsf3.S) anticorps
  • serine and arginine rich splicing factor 3 (Srsf3) anticorps
  • serine/arginine-rich splicing factor 3a (srsf3a) anticorps
  • AL024116 anticorps
  • sfrs3 anticorps
  • si:zc263a23.9 anticorps
  • SRP20 anticorps
  • X16 anticorps
  • zgc:86626 anticorps

Protein level used designations for SRSF3

pre-mRNA-splicing factor SRP20 , splicing factor, arginine/serine-rich 3 , splicing factor, arginine/serine-rich, 20-kD , splicing factor, arginine/serine-rich 3 (SRp20) , splicing factor, arginine serine-rich 3 , splicing factor, arginine/serine-rich 3a

6428 Homo sapiens
20383 Mus musculus
380152 Xenopus laevis
419815 Gallus gallus
403687 Canis lupus familiaris
540276 Bos taurus
361814 Rattus norvegicus
368925 Danio rerio
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