serine/threonine Kinase 24 Protéines (STK24)

The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. De plus, nous expédions serine/threonine Kinase 24 Anticorps (112) et serine/threonine Kinase 24 Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
STK24 8428 Q9Y6E0
STK24 223255 Q99KH8
STK24 361092 B0LT89
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Top serine/threonine Kinase 24 Protéines sur

Showing 9 out of 11 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Baculovirus infected Insect Cells Humain His tag 50 μg 14 to 16 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
Levure Rat His tag   1 mg 60 to 71 Days
Cellules d'insectes Humain GST tag   10 μg 3 to 4 Days

STK24 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Plus protéines pour serine/threonine Kinase 24 (STK24) partenaires d'interaction

Human serine/threonine Kinase 24 (STK24) interaction partners

  1. Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation.

  2. High MST3 expression is associated with breast cancer.

  3. This study demonistrated that MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.

  4. This review notes that in the SOK1 and MST4 germinal center kinase III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3.

  5. These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 family protein kinases.

  6. results show that a STRADalpha-rac1-PAK1 pathway regulates cell polarity and invasion in LKB1-null cells. It also suggests that while the function of LKB1 and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles

  7. mechanism of regulation of MST3

  8. Striatin orchestrates the regulation of Mst3 by PP2A.

  9. Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts.

  10. five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine.

  11. The mammalian sterile 20-like serine/threonine protein kinase 3 (Mst3) plays an essential role in the staurosporine-induced apoptosis of HeLa cells.

  12. Proteolytic activation of Mst3 by caspases.

  13. Mst3 contains signals which may cooperate to control the subcellular distribution of Mst3.

  14. Activation of NDR2 is a multistep process involving phosphorylation of the hydrophobic motif site Thr444/2 by MST3.

  15. MST3 inhibits cell migration in a fashion dependent on autophosphorylation and may regulate paxillin phosphorylation through tyrosine phosphatase PTP-PEST

  16. study demonstrated the essential role of Mst3, a human Ste20-like protein kinase, in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery

  17. Our results reveal that H2O2-induced MST3-mediated cell death involves suppressing both a JNK survival pathway and up-regulation of HO-1.

Mouse (Murine) serine/threonine Kinase 24 (STK24) interaction partners

  1. Stk3/4 (Mst1/2) are important regulators for glucose uptake during osteoblast differentiation.

  2. Mst1 (Stk4) and Mst2 (Stk3) are therefore required for follicular B cells to acquire the ability to recirculate and also to migrate to the splenic red pulp in order to generate marginal zone B cells. In addition B-1 a B cell development is defective in the absence of Mst1.

  3. Our findings suggest that Stk24 plays an important role in controlling IL-17-triggered inflammation and autoimmune diseases.

  4. our study reveals a role of Mst1-Mst2 in maintaining the Treg cell pool and functional fitness in vivo, by amplifying IL-2R-STAT5 signal strength and promoting Treg cell migratory ability and access to IL-2.

  5. show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cellular redox balance by modulating the stability of antioxidant transcription factor Nrf2.

  6. This is the first study reporting that MST3, a Ste20-like kinase, exerts a conserved regulatory role in sodium homeostasis after high-salt diet and in the development of hypertension.

  7. findings identify Mst1/2 as selective drivers of CD8alpha(+) dendritic cell function by integrating metabolic activity and cytokine signalling, and highlight that the interplay between immune signalling and metabolic reprogramming underlies the unique functions of dendritic cell subsets

  8. MST3 inhibits the insulin signalling pathway and is important in the development of insulin resistance and impaired blood glucose levels after an HFD.

  9. It is involved in apoptosis and serine/threonine kinase 3 (STK3) is a recently identified caspase-6 substrate.

  10. Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 target genes and hepatocyte proliferation.

  11. Studies indicate that Hippo (Hpo; MST1/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.

  12. Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB pathway

  13. the TLR-Mst1-Mst2-Rac signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity

  14. Hippo signaling is an endogenous repressor of adult cardiomyocyte renewal and regeneration.

  15. These data indicate that that inhibition of mammalian sterile 20-like kinase 1 rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy

  16. Phosphorylation of LC3 by the STK3 and STK4 is essential for autophagy.

  17. These results identify MST2, not MST1, as a critical regulator of caspase-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.

  18. results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart

  19. Mst1/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.

  20. Mst3 phosphorylates RhoA at Ser26, thereby negatively regulating the activity of RhoA in neurons.

Zebrafish serine/threonine Kinase 24 (STK24) interaction partners

  1. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.

Cow (Bovine) serine/threonine Kinase 24 (STK24) interaction partners

  1. Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression

Profil protéine serine/threonine Kinase 24 (STK24)

Profil protéine

The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3\; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2\; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000

Gene names and symbols associated with STK24

  • serine/threonine kinase 24 (STK24)
  • serine/threonine kinase 24 (Stk24)
  • serine/threonine kinase 24b (STE20 homolog, yeast) (stk24b)
  • serine/threonine-protein kinase 24 (ATEG_04314)
  • serine/threonine-protein kinase 24 (ATEG_09179)
  • serine/threonine-protein kinase 24 (UREG_03984)
  • serine/threonine-protein kinase 24 (BDBG_07988)
  • serine/threonine-protein kinase 24 (MCYG_07323)
  • serine/threonine kinase 3 (Stk3)
  • serine/threonine kinase 24 L homeolog (stk24.L)
  • 0610042I06Rik Protéine
  • 1810013H02Rik Protéine
  • C76483 Protéine
  • mess1 Protéine
  • MST Protéine
  • MST-3 Protéine
  • Mst2 Protéine
  • mst3 Protéine
  • mst3b Protéine
  • RGD1561742 Protéine
  • ste20 Protéine
  • stk3 Protéine
  • stk24 Protéine
  • wu:fi29b08 Protéine
  • zgc:66137 Protéine

Protein level used designations for STK24

STE20-like kinase 3 , STE20-like kinase MST3 , mammalian STE20-like protein kinase 3 , serine/threonine kinase 24 (STE20 homolog, yeast) , serine/threonine-protein kinase 24 , sterile 20-like kinase 3 , mammalian sterile twenty 3 kinase , MST-2 , STE20-like kinase MST2 , mammalian STE20-like protein kinase 2 , protein kinase homolog , serine/threonine-protein kinase 3 , serine/threonine kinase 24 (STE20 homolog) , serine/threonine kinase 24 L homeolog

8428 Homo sapiens
223255 Mus musculus
361092 Rattus norvegicus
406786 Danio rerio
418780 Gallus gallus
4320306 Aspergillus terreus NIH2624
4353910 Aspergillus terreus NIH2624
8444766 Uncinocarpus reesii 1704
8508737 Ajellomyces dermatitidis SLH14081
9227971 Arthroderma otae CBS 113480
100101492 Bos taurus
56274 Mus musculus
444155 Xenopus laevis
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