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STK36 encodes a member of the serine/threonine kinase family of enzymes. De plus, nous expédions STK36 Protéines (4) et et beaucoup plus de produits pour cette protéine.
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Human Polyclonal STK36 Primary Antibody pour ELISA - ABIN542453
Maloveryan, Finta, Osterlund, Kogerman: A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. dans Journal of cell communication and signaling 2008
Data identified homozygous loss-of-function mutations in STK36 in one PCD-affected individual with situs solitus. Transmission electron microscopy analysis demonstrates that STK36 is required for cilia orientation in human respiratory epithelial cells, with a probable localization of STK36 between the RS and CP. STK36 screening can now be included for this rare and difficult to diagnose PCD subgroup.
Fu ubiquitination and cleavage is one of the key elements connecting the MID1-PP2A protein complex with GLI3 activity control
The FU gene and its genomic structure was identified.
Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
Hydrocephalus and suppurative otitis media indicate dysfunction of motile cilia in Stk36 null mice
This growth inhibition is partially rescued by expression of ectopic Gli1, suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.
mouse Fu is essential for construction of the central pair apparatus of motile, 9+2 cilia
zebrafish Fu is required both for Hh signalling and cilia biogenesis in Kupffer's vesicle [fused]
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants.
, serine/threonine-protein kinase 36
, serine/threonine kinase 36 (fused homolog, Drosophila)
, serine/threonine kinase 36, fused homolog
, serine/threonine kinase 36
, serine/threonine-protein kinase 36-like