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The product encoded by SERPIND1 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. De plus, nous expédions serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Anticorps (64) et serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Protéines (17) et beaucoup plus de produits pour cette protéine.
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Mouse (Murine) SERPIND1 Kit ELISA pour Sandwich ELISA - ABIN415743
Kalle, Papareddy, Kasetty, Tollefsen, Malmsten, Mörgelin, Schmidtchen: Proteolytic activation transforms heparin cofactor II into a host defense molecule. dans Journal of immunology (Baltimore, Md. : 1950) 2013
Show all 2 Pubmed References
The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ...
We found that SERPIND1 may act as a potential oncogene (Montrer RAB1A Kits ELISA) in the development of ovarian cancer
Molecular modelling of HCII 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67.
In this study, we demonstrate a previously unknown role for HCII in host defense.
HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK (Montrer PRKAA1 Kits ELISA)-eNOS (Montrer NOS3 Kits ELISA) signaling pathway.
Plasma heparin cofactor II activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction.
[REVIEW]HCII protects against vascular remodeling, including atherosclerosis
potential for oversulfated disaccharides in controlling HCII-regulated thrombin (Montrer F2 Kits ELISA) generation
Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote
role of basic amino acids of the A helix of heparin cofactor II in heparin- or dermatan sulfate-mediated thrombin (Montrer F2 Kits ELISA) inhibition.
In this study, we demonstrate a previously unknown role for HCII in host defense
HCII mediates the antithrombotic effect of porcine skin dermatan sulfate after injury to the carotid arterial endothelium in mice.
In HCII(+/-) mice, prominent intimal hyperplasia with increased cellular proliferation was observed after tube cuff and wire vascular injury.
HCII deficiency promotes atherogenesis and neointima formation
The reactions with thrombin (Montrer F2 Kits ELISA) or APC (Montrer APC Kits ELISA) of recombinant alpha(1)-PI (Montrer SERPINA1 Kits ELISA) M358R variants with or without the HCII extension were characterized electrophoretically and kinetically
These results support the hypothesis that HCII interacts with dermatan sulfate in the vessel wall after disruption of the endothelium and that this interaction regulates thrombus formation in vivo.
The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.
heparin cofactor 2
, leuserpin 2
, protease inhibitor leuserpin-2
, serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
, serpin D1
, heparin cofactor II
, serine (or cysteine) peptidase inhibitor, clade D, member 1
, serine (or cysteine) proteinase inhibitor, clade D, member 1
, serpin peptidase inhibitor, clade D (heparin cofactor), member 1
, heparin cofactor 2-like
, serpin peptidase inhibitor, clade D, member 1