serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) Kits ELISA

The product encoded by SERPIND1 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. De plus, nous expédions serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Anticorps (96) et serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Protéines (21) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SERPIND1 3053 P05546
SERPIND1 79224 Q64268
SERPIND1 15160 P49182
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Top serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Kits ELISA sur anticorps-enligne.fr

Showing 10 out of 34 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Souris 0.069 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 to 16 Days
$682.11
Détails
Humain 0.312 pg/mL 1.25-80 pg/mL Typical standard curve 96 Tests 13 to 16 Days
$1,026.67
Détails
Lapin 1.03 U/L 3.12 U/L - 200 U/L 96 Tests 13 to 16 Days
$720.00
Détails
Rat 3.3 ng/mL 7.81 ng/mL - 500 ng/mL 96 Tests 13 to 16 Days
$720.00
Détails
Cobaye 1.0 U/L 10-250 U/L   96 Tests 15 to 18 Days
$707.14
Détails
Singe 0.1 ng/mL 0.5-10 ng/mL   96 Tests 15 to 18 Days
$707.14
Détails
Porc
  96 Tests 15 to 18 Days
$707.14
Détails
Chien 1.0 U/L 10-250 U/L   96 Tests 15 to 18 Days
$707.14
Détails
Humain 0.123 ng/mL n/a   96 Tests 11 to 16 Days
$693.00
Détails
Mouton
  96 Tests 15 to 18 Days
$707.14
Détails

serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 Kits ELISA mieux référencés

  1. Mouse (Murine) SERPIND1 Kit ELISA pour Sandwich ELISA - ABIN415743 : Kalle, Papareddy, Kasetty, Tollefsen, Malmsten, Mörgelin, Schmidtchen: Proteolytic activation transforms heparin cofactor II into a host defense molecule. dans Journal of immunology (Baltimore, Md. : 1950) 2013 (PubMed)
    Show all 2 Pubmed References

Plus Kits ELISA pour serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 partenaires d'interaction

Human serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) interaction partners

  1. Loss of Heparin Cofactor is associated with insulin resistance .

  2. The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ...

  3. We found that SERPIND1 may act as a potential oncogene in the development of ovarian cancer

  4. Molecular modelling of HCII 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67.

  5. heparin co-factor II is a novel metastasis enhancer and may be used as a prognostic predictor for heparin treatment in non-small cell lung cancer

  6. In this study, we demonstrate a previously unknown role for HCII in host defense.

  7. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK-eNOS signaling pathway.

  8. Plasma heparin cofactor II activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction.

  9. [REVIEW]HCII protects against vascular remodeling, including atherosclerosis

  10. potential for oversulfated disaccharides in controlling HCII-regulated thrombin generation

  11. Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote

  12. role of basic amino acids of the A helix of heparin cofactor II in heparin- or dermatan sulfate-mediated thrombin inhibition.

  13. Altering heparin cofactor II at VAL439 (P6) either impairs inhibition of thrombin or confers elastase resistance.

  14. The interactions of HCII with various heparins in solution competition experiments using SPR show that while calcium enhances this interaction, the activity of heparin-HCII complex against thrombin is not calcium dependent but can be enhanced by it.

  15. structure analysis of the thrombin-heparin cofactor II complex

  16. An asymptomatic Glu428Lys mutation affecting a conserved glutamate at the hinge (P17) of the reactive loop confirms the key structural role of the P17 glutamate in serpins.

  17. after receiving stent for peripheral artery disease, patients with a high HCII activity had a 0.39-fold reduced risk for instent restenosis

  18. HCII activity increases during pregnancy, and HCII levels are significantly decreased in women with severe pre-eclampsia.

  19. These results suggest that transfer of the N-terminal acidic extension of HCII to alpha1-PI M358R enhanced its inhibition of thrombin by conferring the ability to bind exosite 1 on HAPI M358R.

  20. Beta2-glycoprotein I (B2G1) protected thrombin against inactivation by HCII (heparin cofactor II)/heparin

Mouse (Murine) serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) interaction partners

  1. Trancriptomic analysis shows that expression of the antithrombins serpin C1 and D1 is significantly reduced in Schwann cell-deficient mice. In the absence of peripheral neuromuscular activity, neurodegeneration is completely blocked, and expression of prothrombin in muscle is markedly reduced.

  2. Loss of Heparin Cofactor is associated with insulin resistance .

  3. In this study, we demonstrate a previously unknown role for HCII in host defense

  4. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK-eNOS signaling pathway.

  5. HCII mediates the antithrombotic effect of porcine skin dermatan sulfate after injury to the carotid arterial endothelium in mice.

  6. In HCII(+/-) mice, prominent intimal hyperplasia with increased cellular proliferation was observed after tube cuff and wire vascular injury.

  7. HCII deficiency promotes atherogenesis and neointima formation

  8. The reactions with thrombin or APC of recombinant alpha(1)-PI M358R variants with or without the HCII extension were characterized electrophoretically and kinetically

  9. These results support the hypothesis that HCII interacts with dermatan sulfate in the vessel wall after disruption of the endothelium and that this interaction regulates thrombus formation in vivo.

serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1 (SERPIND1) profil antigène

Antigen Summary

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.

Gene names and symbols associated with SERPIND1

  • serpin family D member 1 (SERPIND1) anticorps
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 L homeolog (serpind1.L) anticorps
  • serpin family D member 1 (Serpind1) anticorps
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (serpind1) anticorps
  • serine (or cysteine) peptidase inhibitor, clade D, member 1 (Serpind1) anticorps
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (SERPIND1) anticorps
  • AA985900 anticorps
  • AI303446 anticorps
  • D22S673 anticorps
  • HC2 anticorps
  • Hcf2 anticorps
  • HCII anticorps
  • HLS2 anticorps
  • LS2 anticorps
  • MGC53936 anticorps
  • rls2var1 anticorps
  • serpind1 anticorps
  • THPH10 anticorps

Protein level used designations for SERPIND1

heparin cofactor 2 , leuserpin 2 , protease inhibitor leuserpin-2 , serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 , serpin D1 , heparin cofactor II , HC-II , leuserpin-2 , serine (or cysteine) peptidase inhibitor, clade D, member 1 , serine (or cysteine) proteinase inhibitor, clade D, member 1 , serpin peptidase inhibitor, clade D (heparin cofactor), member 1 , heparin cofactor 2-like , serpin peptidase inhibitor, clade D, member 1

GENE ID SPECIES
3053 Homo sapiens
380511 Xenopus laevis
79224 Rattus norvegicus
359841 Danio rerio
696950 Macaca mulatta
100467362 Ailuropoda melanoleuca
100542650 Meleagris gallopavo
100596966 Nomascus leucogenys
100629879 Equus caballus
15160 Mus musculus
395877 Gallus gallus
100155945 Sus scrofa
100125764 Bos taurus
100009170 Oryctolagus cuniculus
100682658 Canis lupus familiaris
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