anti-serpin Peptidase Inhibitor, Clade H (Heat Shock Protein 47), Member 1, (Collagen Binding Protein 1) (SERPINH1) Anticorps

SERPINH1 encodes a member of the serpin superfamily of serine proteinase inhibitors. De plus, nous expédions SERPINH1 Kits (25) et SERPINH1 Protéines (18) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SERPINH1 12406 P19324
SERPINH1 871 P50454
SERPINH1 29345 P29457
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Top anti-SERPINH1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 193 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Chien Lapin Inconjugué IP, WB IP Suggested Anti-SERPINH1 Antibody Positive Control: NT2 CELL/BRAIN TISSUE 100 μL 2 to 3 Days
$229.00
Détails
Poulet Lapin Inconjugué IP, IHC, WB Western blot analysis of Hsp47 expression in mouse small intestine tissue lysate. 100 μg 2 to 3 Days
$265.00
Détails
Humain Lapin Inconjugué IHC (p), WB WB Image HSP47 antibody [N2C2], Internal detects HSP47 protein by western blot analysis. A. 30 μg A431 whole cell lysate/extract B. 30 μg HeLa whole cell lysate/extract C. 30 μg HepG2 whole cell lysate/extract 10 % SDS-PAGE HSP47 antibody [N2C2], Internal , dilution: 1:500 WB Image HSP47 antibody [N2C2], Internal detects HSP47 protein by western blot analysis. A. 30 μg U87-MG whole cell lysate/extract B. 30 μg SK-N-SH whole cell lysate/extract C. 30 μg IMR32 whole cell lysate/extract D. 30 μg SK-N-AS whole cell lysate/extract 10 % SDS-PAGE HSP47 antibody [N2C2], Internal , dilution: 1:500 100 μL 3 to 4 Days
$466.18
Détails
Humain Lapin Inconjugué IHC (p), WB Anti- Hsp47 Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue Anti- Hsp47 Picoband antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg 4 to 6 Days
$280.00
Détails
Cobaye Souris Inconjugué IHC, IHC (p), WB Human Adrenal (formalin-fixed, paraffin-embedded) stained with SERPINH1 antibody ABIN462363 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Tonsil (formalin-fixed, paraffin-embedded) stained with SERPINH1 antibody ABIN462363 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$727.83
Détails
Humain Lapin Inconjugué IF, IHC, WB 100 μL 11 to 13 Days
$366.77
Détails
Poulet Souris Inconjugué ELISA, IHC, IHC (p), WB Human Colon (formalin-fixed, paraffin-embedded) stained with SERPINH1 antibody ABIN364502 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Uterus (formalin-fixed, paraffin-embedded) stained with SERPINH1 antibody ABIN364502 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$727.83
Détails
Humain Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of HSP47 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of HepG2 cell lysate, using SERPINH1 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277239 at 1/100 staining Human cervical cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Détails
Humain Souris FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Hsp47 Monoclonal Antibody, Clone 1C4-1A6 . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Mouse Anti-Hsp47 Monoclonal Antibody  at 1:100 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Endoplasmic reticulum lumen. Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-Hsp47 Antibody. (C) Composite. Western Blot analysis of Human Epithelial cell (A431) lysates showing detection of ~47 kDa Hsp47 protein using Mouse Anti-Hsp47 Monoclonal Antibody, Clone 1C4-1A6 . Lane 1: MW ladder. Lane 2: Anti-Hsp47 (1:250). Lane 3: Anti-Hsp47 (1:500). Lane 4: Anti-Hsp47 (1:1000). Load: 20 µg. Block: 5% milk + TBST for 1 hour at RT. Primary Antibody: Mouse Anti-Hsp47 Monoclonal Antibody  at 1:250 - 1:1000 for 1 hour at RT. Secondary Antibody: HRP Goat Anti-Mouse at 1:50 for 1 hour at RT. Color Development: TMB solution for 10 min at RT. Predicted/Observed Size: ~47 kDa. 200 μg 3 to 4 Days
$586.30
Détails

anti-SERPINH1 Anticorps mieux référencés

  1. Chicken Polyclonal SERPINH1 Primary Antibody pour IP, IHC - ABIN223215 : Cheng, Pollock, Mahimkar, Olson, Lovett: Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 (PubMed)

  2. Human Polyclonal SERPINH1 Primary Antibody pour IHC, WB - ABIN3023328 : Hu, Du, Shelton, Oldham, DiPersio, Klein: An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. dans Cell stem cell 2018 (PubMed)

  3. Human Polyclonal SERPINH1 Primary Antibody pour IF (p), IHC (p) - ABIN731033 : Kawai, Ogawa, Shimmura, Ohta, Suzuki, Kawamura, Kuwana, Kawakami, Tsubota: Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease. dans Scientific reports 2013 (PubMed)

  4. Human Polyclonal SERPINH1 Primary Antibody pour ICC, IF - ABIN4320133 : Capone, Clemente, Restelli, Di Campli, Sperduti, Ornaghi, Pietrangelo, Protasi, Chiesa, Sallese: PERK inhibition attenuates the abnormalities of the secretory pathway and the increased apoptotic rate induced by SIL1 knockdown in HeLa cells. dans Biochimica et biophysica acta. Molecular basis of disease 2019 (PubMed)

Plus d’anticorps contre SERPINH1 partenaires d’interaction

Mouse (Murine) serpin Peptidase Inhibitor, Clade H (Heat Shock Protein 47), Member 1, (Collagen Binding Protein 1) (SERPINH1) interaction partners

  1. HSP47 on the platelet surface interacts with collagen, stabilizes platelet adhesion and increases collagen-mediated signalling to mediate thrombus formation and hemostasis.

  2. Increased Hsp47 expression is associated with collagen-related disorders such as fibrosis, characterized by abnormal collagen accumulation, highlighting Hsp47's potential as a clinically relevant therapeutic target.

  3. These results highlight a cascade of fibrosis in chronic GVHD; macrophage production of transforming growth factor beta mediates fibroblast differentiation to HSP47(+) myofibroblasts that produce collagen. VA-lip HSP47 represent a novel strategy to modulate fibrosis in chronic GVHD by targeting HSP47(+) myofibroblasts without inducing immunosuppression.

  4. The HSP47 might exert influence on liver fibrosis via the regulation ofendothelin receptor A (ETAR) and endothelin receptor B (ETBR).

  5. miR-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 expression.

  6. HSP47 appears after a period of certain activities to repair damaged collagen fibers, and the activity was returned to a state of equilibrium at day 30 with significantly diminished expression. Thus, the results suggest that HSP47 is actively involved in homeostasis of periodontal tissue subjected to occlusal overload

  7. Intradermal administration of siHSP47-nanoparticles effectively reduced HSP47 protein expression in skin to normal level.

  8. 2014). Data show that the expression of heat shock protein 47 (HSP47) was increased in the scleroderma mouse model.

  9. Deletion of Hsp47 caused activated hepatic stellate cells to undergo ER stress-mediated apoptosis when autophagy was inhibited

  10. Mouse embryonic stem cell migration and differentiation into smooth muscle cells is induced by the over-expression of HSP47.

  11. Authors conclude that heat shock protein 47 plays an essential role in Schistosoma japonicum-induced hepatic fibrosis in mice.

  12. miR-29b down-regulates HSP47 and LOX expression.

  13. expression patterns of HSP70 and HSP47 in tissues following short-pulse laser irradiation

  14. The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster.

  15. These results demonstrate that Hsp47 is indispensable for well-organized cartilage and normal endochondral bone formation.

  16. overexpression of HSP47 in keloid fibroblast cells could induce excessive collagen accumulation by enhancing collagen synthesis, which not only presents a possible mechanism of keloid formation

  17. alpha-smooth-muscle-actin-positive myofibroblast of bleomycin-induced pulmonary fibrosis cells may synthesize procollagen in the fibrotic process of bleomycin-treated lungs through upregulation of HSP47 mRNA and play an important role in fibrogenesis.

  18. HSP47 localized in alpha-smooth muscle actin-positive myofibroblasts, F4/80 negative, surfactant protein-A-positive type II pneumocytes, and F4/80-positive macrophages. Cells may play role in fibrotic process through upregulation of HSP47.

  19. Results indicate that Hsp47 is required for the molecular maturation of type IV collagen and suggest that misfolded type IV collagen causes abnormal morphology of embryoid bodies.

  20. type IV collagen in dilated endoplasmic reticulum leads to apoptosis in Hsp47-knockout mouse embryos via induction of CHOP

Human serpin Peptidase Inhibitor, Clade H (Heat Shock Protein 47), Member 1, (Collagen Binding Protein 1) (SERPINH1) interaction partners

  1. HSP47 on the platelet surface interacts with collagen, stabilizes platelet adhesion and increases collagen-mediated signalling to mediate thrombus formation and hemostasis.

  2. Increased Hsp47 expression is associated with collagen-related disorders such as fibrosis, characterized by abnormal collagen accumulation, highlighting Hsp47's potential as a clinically relevant therapeutic target.

  3. It could be concluded that LF is a promising antifibrotic drug and could be considered as one of the HSP47 inhibitors but SM is still more potent

  4. SERPINH1 was directly regulated by the miR-29 family, and its overexpression was detected in renal cell carcinoma surgical specimens and tyrosine kinase inhibitor failure autopsy specimens. High expression of SERPINH1 was significantly associated with tumor stage, pathological grade and poor prognosis.

  5. SERPINH1 is an independent precision predictor for unfavourable prognosis in clear cell renal cell carcinoma.

  6. HSP47 a well-established endoplasmic reticulum-resident collagen chaperone, also binds decorin, lumican, and fibromodulin with affinities comparable with that in the Hsp47-type I collagen interaction.

  7. Our present data suggest that HSP47 is an important prognostic factor and an attractive therapeutic target in laryngeal squamous cell carcinoma (LSCC)due to its influence on the biological behaviour of LSCC cells

  8. an endoplasmic reticulum complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2.

  9. These observations indicate that this system is appropriate for detecting the interaction between HSP47 and collagen, and could be applied to high-throughput screening for drugs capable of suppressing and/or curing fibrosis.

  10. miR-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 expression.

  11. HSP47 expression in patients with colorectal cancer and the number of HSP47-positive spindle cells in the tumor stroma were significantly higher compared with those in adjacent normal colonic mucosa, and the number of the latter cells increased with tumor progression.

  12. The essential parts of the Golgi stress response from the perspective of the organelle autoregulation. The pathways of the mammalian Golgi stress response have been identified, specifically the HSP47 pathway.

  13. Overexpression of LOXL2 and SERPINH1 was observed in clinical specimens of lung cancer and fibrotic lesions. Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF, suggesting that these genes are involved in the pathogenesis of these two diseases.

  14. The changes in the SERPINH1 and SERPINF1 genes in patients with osteogenesis imperfect were synonymous polymorphisms or missense changes located in non-coding regions.

  15. Overexpression of HSP47 is associated with poor prognosis in patients with esophageal squamous cell carcinoma and this is consistent with the function of HSP47 in terms of increased cell proliferation and colony formation.

  16. A novel homozygous variant in SERPINH1 associated with a severe, lethal presentation of osteogenesis imperfecta with hydranencephaly.

  17. The present study demonstrates that HSP47 promotes glioma angiogenesis and highlights the importance of HSP47 as an attractive therapeutic target of GBM.

  18. Although the chemical chaperone 4-PBA partially restores the solubility of the Hsp47 OI mutants, collagen-binding activity of Hsp47 was not improved.

  19. Data show that the expression of heat shock protein 47 (HSP47) was increased in the peripheral blood mononuclear cells and plasma from scleroderma patients.

  20. Mutations in the HSP47 and FKBP65 produce a moderately severe form of Osteogenesis imperfect.

SERPINH1 profil antigène

Profil protéine

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.

Gene names and symbols associated with SERPINH1

  • serpin family H member 1 (SERPINH1) anticorps
  • serine (or cysteine) peptidase inhibitor, clade H, member 1 (Serpinh1) anticorps
  • serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) L homeolog (serpinh1.L) anticorps
  • serpin family H member 1 (Serpinh1) anticorps
  • astp3 anticorps
  • BERF-1 anticorps
  • cbp1 anticorps
  • cbp2 anticorps
  • colligin anticorps
  • DKFZp468B197 anticorps
  • gp46 anticorps
  • hsp47 anticorps
  • J6 anticorps
  • OI10 anticorps
  • pig14 anticorps
  • pprom anticorps
  • ra-a47 anticorps
  • SERPINH1 anticorps
  • serpinh2 anticorps

Protein level used designations for SERPINH1

serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) , serine (or cysteine) proteinase inhibitor, clade H, member 1 , Serpin H1 , serpin H1-like , 47 kDa heat shock protein , beta enolase repressor factor 1 , collagen binding protein 1 , collagen-binding protein , serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1 , serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2 , serine (or cysteine) proteinase inhibitor, clade H, member 2 , serine protease inhibitor J6 , serpin H1 , colligin , heat shock protein 47 , serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) , arsenic-transactivated protein 3 , cell proliferation-inducing gene 14 protein , colligin-1 , colligin-2 , rheumatoid arthritis antigen A-47 , rheumatoid arthritis-related antigen RA-A47 , serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2) , GP46 , collagen binding protein 2 , serine (or cysteine) peptidase inhibitor, clade H, member 1 , serine proteinase inhibitor, clade H (heat shock protein 47), member 1 , serpin peptidase inhibitor, clade H, member 1

GENE ID SPECIES
466899 Pan troglodytes
696171 Macaca mulatta
100064560 Equus caballus
100172353 Pongo abelii
100400076 Callithrix jacchus
100597132 Nomascus leucogenys
12406 Mus musculus
396228 Gallus gallus
871 Homo sapiens
100158395 Xenopus laevis
485187 Canis lupus familiaris
510850 Bos taurus
29345 Rattus norvegicus
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