thromboxane A Synthase 1 (Platelet) Protéines (TBXAS1)

TBXAS1 encodes a member of the cytochrome P450 superfamily of enzymes. De plus, nous expédions thromboxane A Synthase 1 (Platelet) Anticorps (94) et thromboxane A Synthase 1 (Platelet) Kits (18) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
TBXAS1 6916 P24557
TBXAS1 21391 P36423
Rat TBXAS1 TBXAS1 24886 P49430
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
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Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
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Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human CYP5A1 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$568.54
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TBXAS1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , , ,
Mouse (Murine)
,

Plus protéines pour thromboxane A Synthase 1 (Platelet) (TBXAS1) partenaires d'interaction

Human thromboxane A Synthase 1 (Platelet) (TBXAS1) interaction partners

  1. Sequencing revealed two novel biallelic variants of unknown significance within the thromboxane A synthase gene, TBXAS1 (c.266T > C; c.989T > C), bioinformatically predicted to disrupt the protein. TBXAS1 mutations result in Ghosal hematodiaphyseal dysplasia (OMIM 231095), the autosomal recessive syndrome associated with abnormal bone structure and BMF (Montrer BMF Protéines).

  2. TXAS1 rs2267679TT and rs41708TT genotypes are associated with carotid plaque vulnerability, platelet activation and TXA2 (Montrer TBXA2R Protéines) levels in ischemic stroke patients.

  3. the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 (Montrer TBXA2R Protéines) synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples.

  4. Single nucleotide polymorphisms of TBXAS1 are associated with susceptibility to gout in ethnic Han males population.

  5. The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant diabetics and in the patients with an allele lacking the *2/*3 CYP2C9 (Montrer CYP2C9 Protéines) gene function and AT/TT polymorphism of the thromboxane synthase gene TBS1.

  6. The carriage of Thromboxane A synthase 1 gene polymorphism AA was shown to affect the risk of clopidogrel resistance.

  7. study suggests that the anti-tumor effect of glycyrrhizin in lung adenocarcinoma is, at least in part, TxAS-dependent.

  8. 12-HHT (Montrer ACVRL1 Protéines) is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi

  9. In this study we have showed, for the first time, a significant role of the minor allele rs6962291 of TBXAS1 in patients with NSAID acute cutaneous hypersensitivity.

  10. The increased Km and decreased Vmax values observed with L357V suggest that this variant may generate less TXA2 (Montrer TBXA2R Protéines) at the low levels of PGH2 expected in vivo, raising the possibility of attenuated signaling through the thromboxane pathway.

Mouse (Murine) thromboxane A Synthase 1 (Platelet) (TBXAS1) interaction partners

  1. the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 (Montrer TBXA2R Protéines) synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples.

  2. 12-HHT (Montrer ACVRL1 Protéines) is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi

  3. TXAS mRNA expression was increased within the vascular wall in mouse models of atherosclerosis with advanced lesions.

  4. thromboxane synthase, prostacyclin synthase (Montrer PTGIS Protéines) and thromboxane receptor (Montrer TBXA2R Protéines) have roles in atherosclerotic lesions and correlate with plaque composition

Profil protéine thromboxane A Synthase 1 (Platelet) (TBXAS1)

Profil protéine

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TBXAS1

  • thromboxane-A synthase (PTRG_00454)
  • thromboxane-A synthase (PTRG_06796)
  • Thromboxane-A synthase (thas)
  • thromboxane A synthase 1 (TBXAS1)
  • thromboxane A synthase 1 (platelet) (tbxas1)
  • thromboxane A synthase 1, platelet (Tbxas1)
  • thromboxane A synthase 1 (Tbxas1)
  • BDPLT14 Protéine
  • CYP5 Protéine
  • CYP5A1 Protéine
  • GHOSAL Protéine
  • TBXAS1 Protéine
  • THAS Protéine
  • TS Protéine
  • TXAS Protéine
  • TXS Protéine
  • wu:fk19d08 Protéine
  • zgc:136708 Protéine

Protein level used designations for TBXAS1

thromboxane-A synthase , Thromboxane-A synthase , thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) , thromboxane A synthase 1 (platelet) , thromboxane-A synthase-like , TXA synthase , cytochrome P450 5A1 , cytochrome P450, family 5, subfamily A, polypeptide 1 , platelet, cytochrome P450, subfamily V , TXS , thromboxane A synthase 1, platelet , ThromboxA ane synthase 1

GENE ID SPECIES
6338652 Pyrenophora tritici-repentis Pt-1C-BFP
6345060 Pyrenophora tritici-repentis Pt-1C-BFP
100306773 Salmo salar
418101 Gallus gallus
463774 Pan troglodytes
482771 Canis lupus familiaris
711748 Macaca mulatta
792041 Danio rerio
100173366 Pongo abelii
100481563 Ailuropoda melanoleuca
100580072 Nomascus leucogenys
6916 Homo sapiens
397112 Sus scrofa
509326 Bos taurus
21391 Mus musculus
24886 Rattus norvegicus
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