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anti-Mouse (Murine) AGTR1a Anticorps:
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Human Polyclonal AGTR1a Primary Antibody pour IF (p), IHC (p) - ABIN677873
Liu, Liu, Tanabe, Maeda, Zou, Komano: Differential effects of angiotensin II receptor blockers on A? generation. dans Neuroscience letters 2014
Study demonstrates a modulatory role of Angiotensin II (Ang II)-Ang II type 1 receptor (AT1-R) in methamphetamine (METH)-induced behavioral effect. The expression of AT1-R is specifically upregulated in the striatum of METH-treated mice. Pharmacological antagonism or genetic deletion of AT1-R attenuates METH-induced behavioral sensitization.
Physiological At1ar signaling in the intimal and medial layers is associated with distinct regulatory processes of aorta homeostasis and function; improper At1ar activity in the vascular endothelium is a significant determinant of thoracic aortic aneurysm development in Marfan syndrome mice.
these data support the expression of AT1A in AVP-producing cells of the supraoptic nucleus but not the paraventricular nucleus
Results provide support of a direct role of BM-derived cells AT1R in Ang II-induced atherosclerosis burden and plaque vulnerability. AT1R activation promotes hepatic mRNA expression of cholesterol-metabolism-related genes and vascular mRNA expression of pro-inflammatory cytokines.
High AT1 receptor expression is associated with myocardial infarction.
GPCR-arrestin complex initiates non-desensitized signalling at the plasma membrane by coupling with ion channels.
the expression of AT2 receptors was significantly increased compared to that of AT1 receptors upon ischemic induction.
Transforming growth factor-beta1 induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor-mediated signaling pathways
High AT1R expression is associated with acute lung injury.
QLQX may improve diabetic cardiac function by regulating AGTR1/ TRPV1-mediated autophagy in STZ-induced diabetic mice.
Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms.
AT1R in antigen-specific CD8(+) T cells regulates expansion, differentiation, and function during effector and memory phases of the response against Plasmodium, which could apply to different infectious agents.
Homocysteine displaces angiotensin II, exaggerating injury in abdominal aortic aneurysm.
Nrf2-mediated stimulation of intrarenal Renin-angiotensin system gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes.
This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney.
The formation of liver metastasis, in a mouse model of colorectal cancer, correlated with collagen deposition in the metastatic area, which was dependent on AT1a signaling.
Perivascular Adipose Tissue Angiotensin II Type 1a Receptor Promotes Vascular Inflammation and Aneurysm formation in apolipoprotein E-deficient (ApoE(-/-)) mice.
Mice lacking the AT1A receptor specifically in LEPR-expressing cells failed to show an increase in resting metabolic rate in response to a high-fat diet and deoxycorticosterone acetate-salt (DOCA-salt) treatments, but blood pressure control remained intact.
In wild-type, total (tNCC) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a receptor knockout mice, tNCC and pNCC increased significantly in males to levels not different from those in females.
This study showed that activation of the AT1a receptor may contribute to maintenance of the glomerular structure against hypertensive renal damage.
These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II receptor activation is transduced to depolarization-dependent Ca(2+) entry and aldosterone secretion.
Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.
Luminal ANG II is internalized as a complex with AT1R/AT2R heterodimers to target endoplasmic reticulum in LLC-PK1 cells, where it might trigger intracellular calcium responses.
These studies provide insight into kidney biology as the first in vivo/in vitro experimental evidence about AT(1)R regulation in response to reduced perfusion of the kidney.
AT1 and AT2 receptors heterodimerize and are involved in the angiotensin II effect on SERCA in proximal kidney tubules.
A critical role for lipid raft microdomains in AGTR1-mediated signal transduction in neonatal glomerular mesengial cells.
AT1 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
receptor for and mediator of vascular remodeling effects of angiotensin II
angiotensin II type-1A receptor
, angiotensin receptor 1
, angiotensin receptor 1a
, type-1A angiotensin II receptor
, vascular type-1 angiotensin II receptor
, angiotensin II receptor 1
, angiotensin II type-1 receptor
, type-1 angiotensin II receptor
, angiotensin II type 1 receptor
, Angiotensin II type-1 receptor
, Type-1 angiotensin II receptor