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anti-Human Angiotensin II Type 2 Receptor Anticorps:
anti-Mouse (Murine) Angiotensin II Type 2 Receptor Anticorps:
anti-Rat (Rattus) Angiotensin II Type 2 Receptor Anticorps:
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Human Polyclonal Angiotensin II Type 2 Receptor Primary Antibody pour ELISA, ICC - ABIN4278731
Hafko, Villapol, Nostramo, Symes, Sabban, Inagami, Saavedra: Commercially available angiotensin II At₂ receptor antibodies are nonspecific. dans PLoS ONE 2013
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Human Monoclonal Angiotensin II Type 2 Receptor Primary Antibody pour FACS - ABIN4895528
Sysoeva, Ageeva, Tyurin-Kuzmin, Sharonov, Dyikanov, Kalinina, Tkachuk: Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor. dans Stem cell research 2018
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Report low expression of AGTR2 in human adrenocortical zona glomerulosa and in aldosterone-producing adenomas and suggest lack of functional role for this protein.
Intracrine action of angiotensin II in mesangial cells: subcellular distribution of angiotensin II receptor subtypes AT1 and AT2
rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on pregnancy-induced hypertension risk among Chinese Han women.
It was found that the AGTR2 A-allele is a candidate genetic marker for top-level power athletes. Carriers of the minor allele (A-allele in males and A/A genotype in females) may possess some molecular advantage in developing muscle strength and power traits.
The effects ofgenetic polymorphisms and diet on the risk of metabolic disorders predisposing to cardiovascular diseases among Malay, Chinese, and South Asian persons are reported.
The genotypes of REN, AT1R and AT2R were not associated with the development of preeclampsia in South African Black women.
These data indicate that Ang II-AT2R regulates human bone marrow MSC migration by signaling through the FAK and RhoA/Cdc42 pathways.
Low levels of AT2R is associated with angiogenesis in bladder cancer.
angiotensin II type 2 receptor activation in inguinal adipocytes opposes norepinephrine-induced uncoupling protein-1 (UCP1) production and aspects of cellular respiration
loss of AT2 R is associated with podocyte loss/dysfunction and is mediated, at least in part, via augmented ectopic hedgehog interacting protein expression in podocytes
In this genomewide association study, we found that variants at the EBF1, EEFSEC, AGTR2, WNT4, ADCY5, and RAP2C loci were associated with gestational duration and variants at the EBF1, EEFSEC, and AGTR2 loci with preterm birth.
crystal structures of human AT2R bound to an AT2R-selective ligand and to an AT1R/AT2R dual ligand, capturing the receptor in an active-like conformation
Suggest a gender-specific association between the AT2R -1332 A/G polymorphism and the occurrence of carotid plaque and the history of cerebrovascular insult in advanced carotid atherosclerosis.
peripheral and central arterial pressures and pulse wave augmentation indexes (AIx(P), AIx(C1), AIx(C2)), pulse wave velocity (PWV), daily urinary sodium excretion were measured and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms.
Significant overrepresentation of AT2R-1332 AA genotype in female multiple sclerosis patients was found, compared to female controls.
These data suggest that AT2R inhibits ligand-induced AT1R signaling through the PKC-dependent pathway.
Ang II-induced upregulation of ATF3 and SUMO1 in vitro and in vivo was blocked by Ang II type I receptor antagonist olmesartan. Moreover, Ang II induced ATF3 SUMOylation at lysine 42, which is SUMO1 dependent
The A1166C polymorphism of AT1R, A1675G and C3123A polymorphisms of AT2R were analyzed. The A1675G polymorphism of AT2R might be associated with preeclampsia
Ten tagging single nucleotide polymorphisms on AGTR1/AGTR2 were genotyped for all subjects with primary aldosteronism and controls.
Regulation of AT2R could contribute to preventing future cardiovascular disease in fetal growth restriction offspring
Study showed that in type 1 diabetes, angiotensin II type 2 receptor may reduce glycaemia and display anti-oxidant and/or anti-inflammatory properties in association with greater vasodilatation in mesenteric arteries and in the renal vasculature, a major target of diabetes.
the expression of AT2 receptors was significantly increased compared to that of AT1 receptors upon ischemic induction.
study identifies AT2R on peripheral MPhis as a critical trigger for pain sensitization at the site of nerve injury, and therefore proposes a translatable peripheral mechanism underlying chronic neuropathic pain.
Data suggest that the anticoagulant effects of rivaroxaban are promoted by angiotensin II via angiotensin type 2 receptor and Mas signaling. These findings are significant for the clinical administration of rivaroxaban.
crosstalk between AT2 receptor stimulation and PPARgamma activation could contribute to attenuation of vascular intimal proliferation
Deletion of AT2 receptor reduced SHP-1 activity and restored VEGF actions, leading to an increased blood flow reperfusion after ischemia in diabetes mellitus.
Our current results reinforce the notion that the AT2R has a physiological role in the conservation of insulin action
Ultra-high doses did not influence the ACE2/AT2R/Mas axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin expression in db/db mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage.
This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney.
AT2R-dependent interleukin-17 production by T lymphocyte is necessary for collateral artery growth.
Altered expression of AT1 and AT2 receptors with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration.
AT2R inhibits adipogenic differentiation in mesenchymal stem cells. Moreover, this inhibitory effect is associated with Wnt10b/beta-catenin signaling.
These results suggest that nerve growth factor-mediated neurite outgrowth is suppressed by AT2 receptor signaling via the nitric oxide-cyclic GMP-PKG pathway.
AT2R expressing neurons make GABAergic synapses onto AVP neurons that inhibit AVP neuronal activity and suppress baseline systemic AVP levels.
Further deletion/mutation analysis revealed that multiple transcription factor binding sites in the +286/+690 region within intron 2 coordinately regulate AT2R transcription. Importantly, +286/+690 enhancer activity was suppressed in CHF mouse skeletal muscle, suggesting that AT2R expression is suppressed in CHF via inhibition of AT2R intronic enhancer activity, leading to lowered muscle regeneration.
This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR.
Hypercholesterolemia blunts the oxidative stress and inflammatory cell recruitment elicited by hypertension in venules through a mechanism that involves AT2 receptor activation.
These results suggest that in the absence of AT2R, wound healing rate is accelerated, but yielded worse skin quality.
Data suggest that AGTR2 (and angiotensin-converting enzyme) mRNA levels are transiently up-regulated in ovarian theca cells during preovulatory period.
endothelial, type 2 receptor-dependent increase in nitric oxide may serve to counterbalance the angiotensin II-dependent vasoconstriction in smooth muscle cells, ultimately regulating pulmonary vascular tone.
data suggest that G alpha(i3), Shc, Grb2, Ras, and Raf-1 link Src to activation of MAPK and to the AT(2)-dependent increase in eNOS expression in PAECs
Abundance of AGTR2 mRNA in granulosa cells was higher in healthy compared with atretic follicles, whereas in theca cells, it did not change
Luminal ANG II is internalized as a complex with AT1R/AT2R heterodimers to target endoplasmic reticulum in LLC-PK1 cells, where it might trigger intracellular calcium responses.
AT1 and AT2 receptors heterodimerize and are involved in the angiotensin II effect on SERCA in proximal kidney tubules.
AT2 receptors are positively coupled to the proliferative response of vascular smooth muscle cells to angiotensin II.
Glomerular eNOS gene expression was studied during postnatal maturation and AT1 receptor inhibition.
Renal AT1R expression was increased by approximately 67% and AT2R expression was decreased by approximately 87% in rabbits with heart failure; however, kidneys from denervated rabbits with heart failure showed a near normalization in the expression of these receptors.
Corneal cells express ACE, AT(1) and AT(2)receptors. ACE inhibitor enalapril decreased corneal angiogenesis in VEGF-induced corneal neovascularization. ACE inhibitors may be novel therapy to treat corneal angiogenesis.
Selective AT(2) receptor stimulation induces a negative inotropic and lusitropic effect, which is modulated by endocardial endothelium and mediated by bradykinin B(2) receptors through NO release and calcium dependent potassium channels activation.
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
angiotensin II type-2 receptor
, type-2 angiotensin II receptor
, AT2 receptor
, angiotensin II type 2 receptor
, angiotensin receptor 2
, angiotensin II receptor type 2
, angiotensin II receptor, type 2
, angiotensin type II receptor
, Type-2 angiotensin II receptor
, angiotensin II subtype 2 receptor, AT2