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Results show negative regulation of HDAC1 (Montrer HDAC1 Protéines) by a Cul3 (Montrer CUL3 Protéines)-REN (Montrer REN1 Protéines) E3 ubiquitin ligase (Montrer MUL1 Protéines) complex.
REN (Montrer REN1 Protéines) is upregulated by neurogenic signals (retinoic acid, EGF (Montrer EGF Protéines), and NGF (Montrer NGFB Protéines)) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation.
REN (Montrer REN1 Protéines) protein enhances caspase-3 (Montrer CASP3 Protéines) activation and antagonizes the Shh (Montrer SHH Protéines) pathway suggesting that this gene may represent a restraint of Shh (Montrer SHH Protéines) signaling.
The current study provides evidence for a possible association of renin gene polymorphisms with essential hypertension in a Han population of northern China.
Plasma renin activity is associated with cardiovascular mortality or heart failure readmissions.
In patients with established atherosclerotic disease undergoing carotid endarterectomy, plasma renin and aldosterone concentrations were not associated with atherosclerotic plaque characteristics. Plasma renin concentration was positively associated with the occurrence of major secondary vascular events.
These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development
The genotypes of REN, AT1R (Montrer AGTR1 Protéines) and AT2R (Montrer AGTR2 Protéines) were not associated with the development of preeclampsia in South African Black women.
Urinary angiotensinogen (Montrer AGT Protéines) and renin excretion are elevated in CKD patients. Both parameters are negatively associated with eGFR (Montrer EGFR Protéines) and these associations are independent of urinary albumin (Montrer ALB Protéines) excretion
Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen (Montrer AGT Protéines) and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease.
Prospective study of consecutive cardiac disease patients referred for cardiac catheterization has revealed distinct cardiac disease condition-associated differences in the frequencies of elevations in plasma renin, plasma aldosterone concentration, and the aldosterone-renin ratio
Renin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF (Montrer VEGFA Protéines).
Data suggest mild primary aldosteronism (PA), where plasma renin activity is not as suppressed, is susceptible to dietary sodium influences on renin and ARR (Montrer SAG Protéines) (aldosterone to renin ratio). Optimal screening for PA should occur under conditions of high dietary sodium intake (rather than condition of low dietary sodium intake as frequently prescribed for patients with hypertension, which may be a symptom of PA).
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
, BTB/POZ domain-containing protein KCTD11
, retinoic acid, EGF, and NGF upregulated
, renin 1 structural
, angiotensin-forming enzyme
, renin precursor, renal