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We demonstrated a strong correlation of CD11c expression, which represents dendritic cells (DCs) , with Tumor-infiltrating lymphocytes (TILs) and TLSs in triple-negative breast cancer (TNBC). Further investigation is warranted to identify therapeutic modalities that facilitate recruitment and activation of DCs.
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This study provides evidence that CD11c is involved in the susceptibility to Behcet's disease in a Chinese Han population.
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The main mechanism of Integrin alphaXbeta2 I-domain binding to RAGE is a charge interaction, in which the acidic moieties of Integrin alphaXbeta2 I-domains, including E244, and D249, recognize the basic residues on the RAGE V-domain encompassing K39, K43, K44, R104, and K107.
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Studies indicate that CD11c+ T-bet+ memory B cells exhibit a distinct transcriptome.
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Studies indicate enriched expression of TBX21 (T-bet), which is important for B cell survival and response to antigen, was observed in CD11c+ B cells.
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CD11c, expressed not only in Hairy cell leukemia but also in dendritic cells, macrophages and monocytes is a differentiation marker for inflammation. Prolonged inflammation in the microenvironment of CLL cells may cause a susceptibility to autoimmune disorders and secondary tumors in CLL, in this way, an increase in mortality.
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We can achieve possible clinical significance of lymphoma tumor microenvironments through CD11c and FOXP3 immunohistochemistry stains in extranodal diffuse large B-cell lymphoma patients receiving R-CHOP therapy.
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Circulating CD11c+ T cells were associated with the expression of multiple adhesion molecules in women, suggesting that these cells have high tissue homing potential. These data suggest that CD11c expression distinguishes a population of circulating T cells during bacterial infection with innate capacity and mucosal homing potential.
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CD8+ T cells of Behcet's disease patients exhibited increased CD11c expression levels, which may contribute to disease pathogenesis.
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High expression of CD11c decreased the risk of death and relapse, and may be regarded as an alternative indicator of favorable prognosis in patients with gastric cancer.
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the CD11c molecule possesses four different cellular patterns in the periprosthetic tissues.
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Data show that secreted aspartic protease 2 (Sap2) of Candida albicans inactivates human macrophage complement factor H (factor H), factor H-receptors CD11b/CD18 and CD11c/CD18.
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Data show that the percentage of CD11c positive antigen presenting cells (CD11c(+) APCs) in the peripheral blood of active pulmonary tuberculosis (APT) patients was much higher than that in the controls.
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Data suggest that blood neutrophils expressing CD11c antigen and EMR2 protein be considered as potential biomarkers for sepsis and systemic inflammatory response syndrome (SIRS), respectively.
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Modification of Levels of Adhesion Molecule Expression of Human Innate Immune Cells by Glycopolymers of Marine Bacteria
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beta2 integrins-mediated chemosensory adhesion and migration of polymorphonuclear leukocytes on the vascular graft surface, bacterial cellulose.
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three of these five genes (CXCL14, ITGAX, and LPCAT2) harbored polymorphisms associated with aggressive disease development in a human GWAS cohort consisting of 1,172 prostate cancer patients.
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infiltration of MBP(+) and CD11c(+) innate immune cells show a significant association with phenotype and disease extent of non-asthmatic chronic rhinosinusitis
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CD11a, CD11c, and CD18 gene polymorphisms and susceptibility to Behcet's disease in Koreans.
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LFA-1 and CR4 alpha chain phosphorylation is needed for chemokine-induced cross-talk to VLA-4
