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Ha, Martins, Khazaie, Han, Chan, Kim: Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. dans Journal of immunology (Baltimore, Md. : 1950) 2008
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Unno, Wakamori, Koike, Uchiyama, Ishikawa, Kubota, Yoshida, Sasakawa, Peters, Mizusawa, Watase: Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6. dans Proceedings of the National Academy of Sciences of the United States of America 2012
Vidal, Aguiar, Phansalkar, McAlpine, Napolitano, Chen, Araújo, Pauli, Bedran-Russo: Galloyl moieties enhance the dentin biomodification potential of plant-derived catechins. dans Acta biomaterialia 2014
Human Cathepsin B Kit ELISA pour Sandwich ELISA - ABIN2683959
Mueller-Steiner, Zhou, Arai, Roberson, Sun, Chen, Wang, Yu, Esposito, Mucke, Gan: Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. dans Neuron 2006
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Mouse (Murine) Cathepsin B Kit ELISA pour Sandwich ELISA - ABIN2683961
Chan, San Segundo, McCormick, Steiner: Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. dans Proceedings of the National Academy of Sciences of the United States of America 1986
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Cathepsin B is involved in the programmed cell death of the fat body during B. mori metamorphosis, and that cathepsin B and cathepsin B contribute to B (Montrer TDO2 Kits ELISA). mori metamorphosis.
in CTSB knockout (KO) mice, running did not enhance adult hippocampal neurogenesis and spatial memory function. Interestingly, in Rhesus monkeys and humans, treadmill exercise elevated CTSB in plasma.
Findings from this community-based cohort of young children show that surrogate markers for cardiovascular disease such as total fat mass, percent body fat, abdominal fat, body fat distribution, maximal oxygen uptake and pulse pressure were all associated with cystatin B (Montrer CSTB Kits ELISA). This was not found for cathepsin L (Montrer CTSL1 Kits ELISA) or cathepsin D (Montrer CTSD Kits ELISA)
Increasing cystatin C (Montrer CST3 Kits ELISA) and cathepsin B reported in serum of colorectal cancer patients.
Interruption of either CCL2 (Montrer CCL2 Kits ELISA)-CCR2 (Montrer CCR2 Kits ELISA) signaling or cathepsin B function significantly impaired perineural invasion (PNI (Montrer SERPINE2 Kits ELISA)).
Expression of CSTA (Montrer CSTA Kits ELISA) was detected in some tumor tissues and many tumor-infiltrating immune cells. Cathepsin B expression was also observed in most tumor tissues and tumor-infiltrating immune cells
Data suggest that expression of CTSB in human glioblastoma cell line can be modulated by dietary factors; here, caffeine decreases tumor size and CTSB expression in mouse xenograft model of glioblastoma; note that caffeine, normally a dietary component, was administered via intraperitoneal injection in these studies.
These results indicate that CST1 (Montrer CST1 Kits ELISA)-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence.
SNPs in NLRP3 (Montrer NLRP3 Kits ELISA) and CTSB, associated with an increased NLRP3 (Montrer NLRP3 Kits ELISA)-inflammasome activation, are protective against the development of active pulmonary tuberculosis.
cathepsin B activity assays identified secreted cathepsin B as responsible for apoA-I (Montrer APOA1 Kits ELISA) cleavage at Ser (Montrer SIGLEC1 Kits ELISA)(228) Importantly
ctsB enhanced neutrophil migration though a putative effect on pseudopod retraction rates.
We have shown that keratolytic winter erythema in South African and Norwegian families is caused by two different tandem duplications in a non-coding genomic region upstream of CTSB.
Using quenched activity-based probes, we identified mouse cathepsin B (CtsB), which is expressed in the lower regions of the hair follicle, as an additional target of mouse Cst6 (Montrer CST6 Kits ELISA)
After phagocytosis, particles can disrupt lysosomes, and inhibitor studies have suggested that the resulting release of a lysosomal protease-cathepsin B-into the cytosol somehow activates NLRP3 (Montrer NLRP3 Kits ELISA).
the roles of CTSB/S and SIRT1 (Montrer SIRT1 Kits ELISA) in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.
Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida Genetic deletion.
Exposure of J774A.1 cells to HOCl or HOSCN resulted in a significant decrease in the activity of the Cys (Montrer DNAJC5 Kits ELISA)-dependent cathepsins B and L, but not the Asp (Montrer C3 Kits ELISA)-dependent cathepsin D (Montrer CTSD Kits ELISA).
cathepsin B (CTSB) inhibition or expression of a CTSB-resistant Dab2 (Montrer DAB2 Kits ELISA) mutant maintains Dab2 (Montrer DAB2 Kits ELISA) expression and shifts long-term TGF-beta (Montrer TGFB1 Kits ELISA)-treated cells from autophagy to apoptosis
study brings forth a yet unappreciated role for Cathepsin B in regulating T cell responses during Leishmania major infection
Our results suggest that the Mucopolysaccharidosis type I mice have progressive heart failure and valve disease, which may be caused by cathepsin B overexpression.
The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
evidence shows cathepsin B activity may not be redox regulated; however, the stability of the enzyme at neutral pH is dependent on redox potential, and on the presence of oxidising agents.
Overexpressing cathepsin B reduced the Vascular Endothelial Growth Factor-dependent tube response
The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase (Montrer ACE Kits ELISA) activity of the protease.
Findings showed that CTSB facilitates adipogenesis, and its effect is associated with fibronectin degradation and Wnt/b-catenin signaling pathway.
CTSB may be required to remodel endometrial and placental tissues for close apposition between maternal and fetal vasculatures and to facilitate transplacental transport of gases, micronutrients (amino acids, glucose), and macromolecules (proteins).
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
, cathepsin B-2744
, cathepsin B-1674
, cathepsin B-84
, cathepsin B-3098
, cathepsin B-16D2
, cathepsin B-1874
, cathepsin B-3483
, cathepsin B-10270
, APP secretase
, amyloid precursor protein secretase
, cathepsin B1
, cysteine protease