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the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO.
presence of MARCO allows rapid Adenovirus (AD) gene expression and strong virus-stimulated innate responses; blockage or lack of MARCO results in strong impairment of these processes;. MARCO is involved in innate Ad recognition and the elevated Ad sensitivity of MARCO-expressing macrophages is due to the expression of this receptor on the cell surface
Common damage-associated molecular patterns (DAMPs) were internalized through the class A scavenger receptors MSR1 and MARCO in vitro. In ischemic murine brain, DAMP internalization was largely mediated by MSR1. Combined deficiency for Msr1 and Marco in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke.
Increasing MARCO expression by targeting Nrf2 signaling or the Akt-TFEB-MARCO pathway are promising strategies to improve bacterial clearance and survival in postinfluenza bacterial pneumonia.
free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria.
this study shows that Marco functions as co-receptor along with TLRs for HMGB1 in M1-type inflammatory macrophages
MARCO Is Processed by either Macropinocytosis or Endocytosis-Autophagy Pathway
our data demonstrate that MARCO differentially affects TLR-induced DC activation and suggest targeting of MARCO could lead to different outcomes that depend on the inflammatory context encountered by dendritic cells.
Vaccinia virus bound directly to MARCO, and overexpression of MARCO increased susceptibility to vaccinia infection.
MARCO-/- dendritic cells demonstrated enhanced migratory capacity in response to CCL-21 in vitro.
herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease.
results indicate that accumulation of SQSTM1 leads to increased activation of NFE2L2 and the subsequent increase in MARCO and MSR1
this study, we confirm that tolerized mouse bone marrow-derived macrophages selectively increase expression of MARCO and increase phagocytosis
MARCO is an important component of anti-Streptococcus pneumoniae responses in murine nasopharyngeal macrophages during bacterial colonization.
Fetuin-A-containing calciprotein particles facilitate the clearance of mineral debris by macrophages via SR-A.
These results indicate that MARCO suppresses a protective early inflammatory response to influenza, which modulates viral clearance and delays recovery.
SR-A/MARCO-mediated rapid ligand internalization prevented sensing by surface TLRs while increasing ligand availability in intracellular compartments, thus allowing sensing and robust responses by intracellular sensors.
MARCO is an important phagocytic receptor used by human and mouse macrophages to clear C. sordellii from the infected uterus
The MARCO receptor may account for the variable species susceptibility towards dalcetrapib-mediated chylomicron uptake by macrophages
TLR4 engagement by LPS leads to increased expression of NARCO, which feedback-regulates LPS responses, changling cytokine & anti-LPS Ab production. MARCO contributes to the efficient capturing & clearance of invading microbial pathogens.
Q452 and F282 are important for ligand association and phagocytosis of bacteria. Q452 and F282 are examples of positively selected mutations in MARCO, and both enhance the intrinsic function of the receptor.
High surface expression of SR-A6 facilitates HAdV-C5 infection.
These data suggest the SRCR domain of MARCO is the key domain in modulating ligand binding, enhancing downstream pro-inflammatory signaling and MARCO-mediated cellular adhesion.
Expression of MARCO declined progressively as hepatocellular carcinoma condition is aggravated.
MARCO single nucleotide polymorphisms rs12998782 increases risk to pulmonary tuberculosis in a Chinese Han population.
CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population.
results suggest that MARCO polymorphisms may regulate phagocytosis of M. tuberculosis and susceptibility and severity of pulmonary tuberculosis
this paper shows that key gene of intermediate proinflammatory monocytes, such as MARCO, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis
this study shows that MARCO modulates inflammatory responses against Cryptococcus neoformans infection
this translational investigation identified gene candidates, including Marco, for host susceptibility to multiple phenotypes of RSV disease in mice that closely mimic human disease, and a polymorphism in human MARCO associated with increased risk of RSV disease severity in infants.
Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO.
identified as a disease-associated molecule in IgG4-related disease by DNA microarray
None of the nonsynonymous variants discovered by resequencing of the structurally similar MARCO were associated with lung function or risk of COPD.
Significant associations of four SNPs and haplotypes with antibody response to cholera vaccine in three genes, MARCO, TNFAIP3 and CXCL12.
We identified 9 non-synonymous variants in the MARCO gene and showed that these variants are not major risk factors for COPD or lung infection. H101Q heterozygotes had increased sepsis risk.
Polymorphisms within the human class A scavenger receptor MARCO correlate with susceptibility/resistance to tuberculosis in a Gambian population.
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
macrophage receptor MARCO
, scavenger receptor class A member 2
, scavenger receptor class A, member 2
, putative scavenger receptor MARCO