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Aperçu des produits pour anti-PIK3AP1 (PIK3AP1) Anticorps

Full name:: anti-phosphoinositide-3-Kinase Adaptor Protein 1 Anticorps (PIK3AP1)

Chez www.anticorps-enligne.fr sont 95 phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) Anticorps de 14 de différents fournisseurs disponibles. De plus, nous expédions PIK3AP1 Protéines (8) et PIK3AP1 Kits (6) et beaucoup plus de produits pour cette protéine. Un total de 111 PIK3AP1 produits sont actuellement listés.

Synonymes:: 1810044J04Rik, BCAP, RP11-34E5.3

afficher tous les anticorps	Gène	GeneID	UniProt
	PIK3AP1	118788	Q6ZUJ8
	PIK3AP1	83490	Q9EQ32
	PIK3AP1	294048
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Pathways pertinentes pour anti-PIK3AP1 Anticorps

Activation of Innate immune Response

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Plus d’anticorps contre PIK3AP1 partenaires d’interaction

Human phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) interaction partners

Dimeric BCAP associates with the TIR domains of TLR2/4 and MAL/TIRAP, suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions.
Abi-1 promotes Abl-mediated BCAP phosphorylation and suggest that Abi-1 in general coordinates kinase-substrate interactions

Mouse (Murine) phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) interaction partners

we showed that BCAP plays an important role in osteoclast differentiation
identify BCAP as a novel inhibitor of myelopoiesis in the steady state and of emergency myelopoiesis during demand conditions
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.
BCAP is an essential activator of the PI3K pathway downstream of TLR signaling.
BCAP is a unique TIR domain-containing toll like receptor (TLR) signaling adapter crucial for linking TLRs to PI3K activation and regulating the inflammatory response.
As macrophages engage their pathogenic targets, innate immune receptors trigger increased expression of BCAP, which endows them with the capacity to withstand further challenges from ongoing cellular insults, such as endoplasmic reticulum stress.
BCAP-(L) (but not BCAP-(S)) is a negative regulator of the TLR-mediated host defense system in macrophages.
plays an immunoregulatory role in B cell development and function--review
BCAP and CD19 have complementary roles in BCR-mediated phosphoinositide 3-kinase activation
model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes functionality, terminal maturation, and long-term survival

PIK3AP1 profil antigène

Antigen Summary

Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity). May be involved in the survival of mature B-cells via activation of REL (By similarity).

Alternative names and synonyms associated with PIK3AP1

phosphoinositide-3-kinase adaptor protein 1 (PIK3AP1) anticorps
phosphoinositide-3-kinase adaptor protein 1 (Pik3ap1) anticorps

1810044J04Rik anticorps
BCAP anticorps
RP11-34E5.3 anticorps

Protein level used designations for PIK3AP1

B cell adaptor protein , B-cell adapter for phosphoinositide 3-kinase , B-cell phosphoinositide 3-kinase adapter protein 1 , phosphoinositide 3-kinase adapter protein 1 , B cell phosphoinositide 3-kinase adaptor

GENE ID	SPECIES
118788	Homo sapiens
83490	Mus musculus
294048	Rattus norvegicus
608653	Canis lupus familiaris
374268	Gallus gallus

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