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S100A15 (Montrer S100A14 Protéines) retains the ability to coordinate zinc through incorporation of an exogenous ligand resulting in a unique zinc-binding site among S100 proteins.
Molecular cloning and characterization of alternatively spliced S100A15 (Montrer S100A14 Protéines) isoforms from psoriatic skin.
The S100A15 (Montrer S100A14 Protéines) protein has been expressed & purified to homogeneity in 2 crystal forms. Crystals of form I are triclinic. Crystals of form II are monoclinic & have a solvent content of 51.8%, corresponding to the presence of 1 monomer in the asymmetric unit.
Overexpression of hS100A15 in chronic inflammatory skin diseases and regulation by inflammatory cytokines and calcium suggest that hS100A15 is involved in Th1 (Montrer TH1L Protéines)-associated epithelial responses and epidermal maturation in normal and diseased human skin
E. coli modulates S100A15 (Montrer S100A14 Protéines) and IL-8 (Montrer IL8 Protéines) expression of keratinocytes by recognition through TLR4 (Montrer TLR4 Protéines).
study defines RAGE (Montrer AGER Protéines) (receptor for advanced glycation end products) as the hS100A7 receptor, whereas hS100A15 functions through a Gi protein-coupled receptor
visfatin (Montrer NAMPT Protéines) enhances CAMP, hBD-2 (Montrer DEFB4 Protéines), hBD-3 (Montrer DEFB103A Protéines), and S100A7 (Montrer S100A7 Protéines) production in human keratinocytes and their orthologs in murine imiquimod-treated psoriatic skin.
These results support the hypothesis that the mouse S100A7 (Montrer S100A7 Protéines) gene is structurally and functionally similar to human S100A7 (Montrer S100A7 Protéines) and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. S00A7
May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.
S100 calcium binding protein A15
, S100 calcium binding protein A7-like 1
, S100 calcium-binding protein A15
, S100 calcium-binding protein A7-like 1
, S100 calcium-binding protein A7A
, protein S100-A7A
, S100 calcium-binding protein A15A
, protein S100-A15A