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ADRA1 expression was greater on vascular smooth muscle in burn scars than in unscarred tissue, and greater on dermal nerve fibres, blood vessels and fibroblasts in keloid scars than in either burn scars or unscarred skin.
This study provided proof that SNPs within ADRA1 is significantly associated with the susceptibility to and the prognosis of cervical vertigo, so that NPY and NA might serve as the precise diagnostic marker and treatment target of cervical vertigo.
Our novel data, describing the alpha1A-AR phosphorylation sites, suggest that the observed different phosphorylation patterns may participate in defining adrenoceptor localization and action, under the different conditions examined
The presence of ADRA1A autoantibodies is an independent predictor for aortic stiffness progression in normotensive subjects.
A mutation of rs2322333, located in the intronic and 3'UTR part of the gene ADRA1A in chromosome 8, has a probability of being deleterious the abolition of ELAV-like protein 1 (ELAVL1) binding site rs2695260. SNP rs2322333 in adrenergic receptor alpha1 (ADRA1A) was higher in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis compared with healthy controls
Demonstrate the utility of alpha1 -AR agonists in the treatment of traction alopecia and hair shedding during cosmetic procedures.
Immunoreactivity for ADRA1A was densely distributed in vascular smooth muscle of nasal turbinates.
alpha1A-adrenoceptor subtypes predominantly contributed to human IAS contraction
Data are presented that indicate that Iso represents a novel type of alpha1A-AR partial agonist with signaling bias toward MAPK/ERK signaling cascade that is likely independent of coupling to Galphaq.
alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts.
Data suggested ADRA1A Arg347Cys polymorphism as susceptibility factor in patients with vasovagal syncope; ArgArg genotype could be a marker for vasovagal syncope susceptibility in the Mexican population
heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction
The ADRA1A mutant triggers two distinct EGFR transactivation-dependent signaling pathways: 1) constitutive Gq-independent beta-arrestin-1/Src/MMP/EGFR/ERK-dependent hyperproliferation and 2) agonist-induced Gq- and EGFR/STAT-dependent hypertrophy.
The alpha-AR-induced mydriasis in mice is mediated mainly by the alphaA-AR, with a smaller contribution of the alphaB-AR, matching the relative abundance of these subtypes at the mRNA level.
alpha1-AR expression is greater on nerve fibers in skin affected by complex regional pain syndrome type II (CRPS) than in unaffected skin from the same patient or from pain-free controls.
Mean alpha-receptor stain rates in renal pelvis were 2.65 +/- 0.74, 1.35 +/- 0.81 and 2.9 +/- 0.30 for alpha 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 +/- 0.82, 1.50 +/- 0.76 and 2.75 +/- 0.44 for alpha 1A, 1B and 1D, respectively.
Adrenergic alpha1A receptor subtypes transactivate epidermal growth factor receptors.
alpha1A-AR, when located in the plasma membrane, signal through calcium and ERK1/2 pathways but, when it translocates to deeper endosomes, continues signaling through ERK1/2 and could also activate the p38 pathway.
Upon receptor activation, prostate alpha1A-adrenoceptors bind clathrin LCA.
Presence of the Arg347 allele in the ADRA1A gene is a risk factor for occurrence of more severe metabolic abnormalities in patients with schizophrenia.
Thinner media and lower alpha1-adrenoceptor expression weaken contractions of breast cancer feed arteries in response to sympathetic activity. We propose that abnormalities in breast cancer arteries can be exploited to modify tumor perfusion and thereby either starve cancer cells or facilitate drug and oxygen delivery during chemotherapy or radiotherapy.
In the mouse bleomycin model of right ventricular failure, the alpha1A-adrenergic receptor subtype agonist A61603 prevents right ventricular failure.
Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration
Male mouse and marmoset proximal urethral smooth muscle shows strong alpha1A- adrenoceptor-induced contractions and abundant alpha1A-adrenoceptor expression, whereas alpha1A-adrenoceptor-mediated mechanisms are much less important in females.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta-mediated GLUT translocation that may be specific to the alpha(1A)-AR subtype.
Our results demonstrate the ability of the D-like dopamine receptors to regulate the expression and activity of alphaA-adrenergic receptor
Data identify a novel, "inside-out" nuclear a1A-subtype/PKCd/cTnI-signaling pathway that regulates contractile function in adult cardiac myocytes.
Male contraception via simultaneous knockout of alpha1A-adrenoceptors and P2X1-purinoceptors in mice.
We have provided the first evidence for specific heteromerization between the alpha(1A)-adrenoceptor (alpha(1A)AR) and CXC chemokine receptor 2 (CXCR2) in live cells.
Co-localization of the alpha1-subtypes at the nuclei in adult cardiac myocytes facilitated the formation of receptor oligomers that could affect receptor signaling.
sustained activation of IL-1 signaling....affects the expression of the ARalpha(1A) subtype..and that modification of adrenergic signaling by the IL-1 system may ultimately cause significant psychiatric abnormalities such as depression
Findings uncover a vascular signaling pathway linking alpha(1)-adrenergic receptors and pressure to WNK1, SPAK, and NKCC1 and may, thus, significantly broaden the comprehension of the regulatory mechanisms of vascular tone in arterial hypertension.
Activation of the adrenergic receptor alpha 1a subtype enhances learning and memory and has antidepressant and antianxiety effects.
result is consistent with coimmunoprecipitation experiments from thoracodorsal resistance arteries, which suggested an association between Pannexin1 and alpha1D-adrenergic receptor
the alpha1A-adrenoceptor plays the major role in noradrenaline-induced contraction in ureters
Use fluorescent ligand binding to examine Adra1a distribution in arteries.
alpha 1A/C-AR subtype is a vasopressor expressed in resistance arteries and is required for normal arterial blood pressure regulation.
alpha(1)-ARs in male mice are required for the physiological hypertrophy of normal postnatal cardiac development and for an adaptive response to cardiac stress
alpha(1A)- and alpha(1B)-adrenoceptors have roles in myocardial contractions
CAM alpha(1A)- and alpha(1B)-ARs both down regulate beta(1)-AR-mediated inotropy in the mouse heart. However, alpha(1)-AR subtypes are coupled to different beta-AR mediated signaling pathways with the alpha(1B)-AR being pertussis toxin sensitive.
These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor with neonatal glucose and lipid metabolism.
modeling of full-length alpha(1a) adrenergic receptor due to its biological role and significant implications in pharmacological treatment of benign prostate hyperplasia
Stimulation of transfected bovine alpha1A-AR promotes cell cycle arrest, hypertrophy and differentiation of fibroblasts into smooth muscle-like cells and expression of negative cell cycle regulators by a mechanism independent of cAMP/PKA signaling
Two distinct adrenoceptor phenotypes (alpha1A and alpha1L) with high and moderate affinities for prazosin are co-expressed in the iris of albino rabbits.
Results suggest that contraction of circular smooth muscle from the pig internal anal sphincter is mediated via alpha1A/L-adrenoceptors.
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.
G protein coupled receptor
, adrenergic, alpha-1A-, receptor variant 1
, adrenergic, alpha-1A-, receptor variant 11
, adrenergic, alpha-1A-, receptor variant 3
, adrenergic, alpha-1A-, receptor variant 5
, adrenergic, alpha-1A-, receptor variant 8
, alpha-1A adrenergic receptor
, alpha-1A adrenoceptor
, alpha-1A adrenoreceptor
, alpha-1C adrenergic receptor
, adrenergic alpha 1c receptor
, adrenergic receptor alpha 1c subtype
, adrenergic receptor, alpha 1a
, adrenergic receptor, alpha 1c
, adrenergic, alpha-1A-, receptor
, alpha 1A-adrenoceptor
, alpha 1A-adrenoreceptor
, alpha 1C-adrenergic receptor
, alpha 1a-adrenoceptor
, alpha-1A-adrenergic receptor
, adrenergic receptor alpha-1A