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anti-Human CAMKK2 Anticorps:
anti-Mouse (Murine) CAMKK2 Anticorps:
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Human Polyclonal CAMKK2 Primary Antibody pour IHC (p), WB - ABIN1882069
Hsu, Chen, Lee, Chi, Cheng, Chen: Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. dans The Journal of biological chemistry 2001
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Human Polyclonal CAMKK2 Primary Antibody pour IF (p), IHC (p) - ABIN716426
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. dans Scientific reports 2016
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Human Monoclonal CAMKK2 Primary Antibody pour ELISA, WB - ABIN524083
Kou, Sartoretto, Michel: Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. dans The Journal of biological chemistry 2009
Human Monoclonal CAMKK2 Primary Antibody pour IP, ELISA - ABIN564643
Karacosta, Foster, Azabdaftari, Feliciano, Edelman: A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression. dans The Journal of biological chemistry 2012
Human Polyclonal CAMKK2 Primary Antibody pour IP, WB - ABIN950067
Krishan, Richardson, Sahni: The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells. dans Biochimica et biophysica acta 2016
Human Polyclonal CAMKK2 Primary Antibody pour ICC, IF - ABIN4287593
Massie, Lynch, Ramos-Montoya, Boren, Stark, Fazli, Warren, Scott, Madhu, Sharma, Bon, Zecchini, Smith, Denicola, Mathews, Osborne, Hadfield, Macarthur, Adryan, Lyons, Brindle, Griffiths, Gleave et al.: The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. ... dans The EMBO journal 2011
14-3-3gamma protein directly interacts with the kinase domain of CaMKK2 and the region containing the inhibitory phosphorylation site Thr (Montrer TRH Anticorps)(145) within the N-terminal extension. CaMKK isoforms differ in their 14-3-3 (Montrer YWHAQ Anticorps)-mediated regulations and the interaction between 14-3-3 protein (Montrer YWHAE Anticorps) and the N-terminal 14-3-3 (Montrer YWHAQ Anticorps)-binding motif of CaMKK2 might be stabilized by small-molecule compounds.
CAMKK2 exhibited the strongest associations with HIV-associated sensory neuropathy (HIV-SN), with two SNPs and six haplotypes predicting SN status in black Southern Africans.
Study used three cognitive tasks and fMRI to provide convergent evidence of a link between the rs1063843 SNP of CAMKK2 and the function of the dorsolateral prefrontal cortex. In addition, this polymorphism was associated with the function of the striatum during a working memory task.
Data suggest that CAMKK2 is highly expressed in high-grade ovarian cancer and ovarian cancer cell lines; CAMKK2 directly activates Akt1 by phosphorylation at Thr-308 in a Ca2+/calmodulin-dependent manner; CAMKK2 knockdown or inhibition decreases Akt1 phosphorylation at Thr-308 and Ser-473. (CAMKK2 = calcium/calmodulin dependent protein kinase kinase 2; AKT1 = AKT serine/threonine kinase 1)
Single nucleotide polymorphism in CAMKK2 gene is associated with pulmonary non-tuberculous mycobacterial disease.
This study showed that the expression level of CAMKK2 could be regulated by promoter methylation. CAMKK2 serves as a prognostic marker in gliomas and could be a potential therapeutic target in gliomas.
For the first time, we showed that rs1063843, a single nucleotide polymorphism located in the CAMKK2 gene, is highly associated with bipolar disorder
Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK (Montrer PRKAA1 Anticorps) but not of CaMKIalpha (Montrer CAMK1 Anticorps).
Clopidogrel diminishes TNFalpha (Montrer TNF Anticorps)-stimulated VCAM-1 (Montrer VCAM1 Anticorps) expression at least in part via HO-1 (Montrer HMOX1 Anticorps) induction and CaMKKbeta/AMPK (Montrer PRKAA1 Anticorps)/Nrf2 (Montrer GABPA Anticorps) pathway in endothelial cells.
CaMKK2 (and Nup62 (Montrer NUP62 Anticorps)) are required for optimal androgen receptor (Montrer AR Anticorps) transcriptional activity in castrate resistant prostate cancer cells.
we demonstrated that systemic administration of the small molecule CaMKK2 inhibitor, STO (Montrer NSD1 Anticorps)-609, to irradiated mice enhanced Hematopoietic stem and progenitor cells (HSPCs)recovery and improved survival. These findings identify CaMKK2 as an important regulator of HSPC (Montrer PSMA7 Anticorps) regeneration and demonstrate CaMKK2 inhibition is a novel approach to promoting hematopoietic recovery after BM injury.
loss of blood-brain barrier proteins, inactivation of survival gene expression such as B-cell lymphoma 2 (Bcl-2 (Montrer BCL2 Anticorps)) and an increase in inflammatory cytokines in the serum were observed after stroke with CaMKK beta inhibition. We demonstrate that CaMKK beta is neuroprotective in stroke in aged mice
CaMKK2 as a molecular rheostat for insulin (Montrer INS Anticorps) action.
CaMKK2 Inhibits C2C12 Myoblasts Proliferation and Differentiation through AMPK (Montrer PRKAA1 Anticorps). Overexpression of CaMKK2 Inhibits Muscle Regeneration in Vivo.
In summary, we demonstrate a new mechanism of calcium dependent antibacterial strategy in E. coli infected macrophages, which requires autophagy enhancement mediated by activation of CaMKKbeta, ERK (Montrer EPHB2 Anticorps), AMPK (Montrer PRKAA1 Anticorps) and FoxO1 (Montrer FOXO1 Anticorps).
CaMKKbeta exerts protective effects on cardiac adaptive energy pooling against pressure-overload possibly through phosphorylation of AMPK and by upregulation of PGC-1alpha.
Results demonstrated that genetically inhibiting the CaMKK pathway via CaMKKbeta or CaMK IV (Montrer CAMK4 Anticorps) is detrimental in the response of female mice to cerebral ischemia
a novel function for CaMKK2 in bone remodeling and highlight the potential for its therapeutic inhibition as a valuable bone anabolic strategy that also inhibits OC differentiation in the treatment of osteoporosis.
Flow-enhanced sirtuin (Montrer SIRT1 Anticorps) (SIRT)1 (Montrer SIRT1 Anticorps) stability is primarily mediated by CaMKKbeta phosphorylation of sirtuin SIRT1 (Montrer SIRT1 Anticorps) at Ser (Montrer SIGLEC1 Anticorps)-27 and Ser (Montrer SIGLEC1 Anticorps)-47.
amino acid starvation regulates autophagy in part through an increase in cellular Ca(2 (Montrer CA2 Anticorps)+) that activates a CaMKK-beta-AMPK (Montrer PRKAA1 Anticorps) pathway and inhibits mTORC1, which results in ULK1 (Montrer ULK1 Anticorps) stimulation
the expression, but not the kinase activity, of AMPK (Montrer PRKAA1 Anticorps) and CaMKKbeta is necessary for ADP signaling to eNOS (Montrer NOS3 Anticorps)
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
CAMKK beta protein
, caM-KK 2
, caM-KK beta
, caM-kinase kinase 2
, caM-kinase kinase beta
, calcium/calmodulin-dependent protein kinase beta
, calcium/calmodulin-dependent protein kinase kinase 2
, caMKK 2
, caMKK beta
, calcium/calmodulin-dependent protein kinase kinase beta
, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
, protein-tyrosine kinase
, calcium/calmodulin-dependent protein kinase II beta
, calcium/calmodulin-dependent protein kinase kinase 2, beta
, calcium/calmodulin-dependent protein kinase kinase 2-like
, Ca+/Calmodulin-dependent protein kinase kinase beta (CaM-kinase kinase beta)
, CaM-kinase kinase beta
, calcium/calmodulin-dependent protein kinase 2 beta