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anti-Mouse (Murine) CPT1C Anticorps:
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Human Polyclonal CPT1C Primary Antibody pour ELISA, WB - ABIN4300343
Sierra, Gratacós, Carrasco, Clotet, Ureña, Serra, Asins, Hegardt, Casals: CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. dans The Journal of biological chemistry 2008
CPT1C in the mediobasal hypothalamus is necessary for proper hypothalamic sensing of a negative energy balance and fuel partitioning in liver and muscle.
data newly identify CPT1C as a regulator of AMPAR translation efficiency and therefore also synaptic function in the hippocampus
Results indicate that altered ceramide metabolism in motor brain areas induced by Cpt1c deficiency causes progressive motor dysfunction from a young age
The expression of CPT1C is induced by metabolic stress factors such as hypoxia and glucose deprivation in a p53 and AMP activated kinase-dependent manner.
ghrelin induces food intake through regulation of hypothalamic CPT1C and ceramide metabolism
CPT1c is not involved in fatty acid beta-oxidation, there were no changes in metabolites associated with fatty acid oxidation.
CPT1C regulates the levels of ceramide in the endoplasmic reticulum of hippocampal neurons
CPT1c can elicit profound effects on brain physiology and total fatty acid profiles, which can be modulated by the nutritional composition of the diet
Data show that the anorectic actions of central leptin or cerulenin are impaired in mice with brain CPT-1c deleted.
cells can use a novel mechanism involving CPT1C and fatty acid metabolism to protect against metabolic stress
CPT1c is necessary for the regulation of energy homeostasis
CPT1c is appropriately localized in regions and cell types to regulate energy homeostasis
Plays a role in maintaining energy homeostasis, but not through altered fatty acid oxidation.
Changes in hepatic and skeletal muscle glucose metabolism are important mechanisms determining the phenotype of Cpt1c knockout mice, rendering them susceptible to glucose intolerance.
Depletion of PPARalpha resulted in low CPT1C expression.
CPT1C binds malonyl-CoA and long-chain acyl-CoA suggest that it is a sensor of lipid metabolism in neurons, where it appears to impact ceramide and triacylglycerol metabolism. [review]
CPT1c is found in brain regions that are related to food intake and neuropsychiatric disease. CPT1c affects ceramide levels, endocannabionoids, and oxidative processes and may play an important role in various brain functions such as learning.
CPT1C mutation associated with novel form of pure autosomal dominant hereditary spastic paraplegia.
High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C.
Data suggest that an involvement of CPT1C in cellular energy-sensing pathways and provide evidence for a role of CPT1C in hypothalamic regulation of energy homeostasis.
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity
Accumulation of 3-hydroxylated intermediates of long-chain fatty acids may contribute to the pathogenesis of retinopathy in MTP deficiencies.
This study evaluated the effects of nonesterified fatty acids and glucose on carnitine palmitoyltransferase-I (CPT-I) mRNA expression in cultured bovine hepatocytes using real-time reverse transcription polymerase chain reaction and ELISA methods.
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene.
, CPT IC
, carnitine O-palmitoyltransferase 1, brain isoform
, carnitine O-palmitoyltransferase I, brain isoform
, carnitine palmitoyltransferase 1, brain
, carnitine palmitoyltransferase I related C
, carnitine palmitoyltransferase 1C