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Fasn-1 regulates antimicrobial peptide nlp-29 expression in a WNK-1 and gck-3 dependent manner.
Genetic interactions at the cell-autonomous level, where glycolytic enzymes or Glo1 were manipulated in FASN mutant cells, revealed that this sugar-dependent size reduction is a direct consequence of MG-derived-AGE accumulation
This work reveals a novel mechanism involved in protrusion formation that is dependent on transient interaction between FASN and protrudin, and establishes a creative strategy to investigate transient protein-protein interactions in mammalian cells.
High FASN expression is associated with gastric adenocarcinoma.
Mutated EGFR mediates tyrosine kinase inhibitor resistance through regulation of the fatty acid synthase (FASN), which produces 16-C saturated fatty acid palmitate.
The study put forward two lead compounds against FASN with favorable pharmacokinetic profile as indicated by virtual screening tools for the development of cancer chemotherapeutics.
Data show that silencing of fatty acid synthase (FASN) and the downstream estrogen receptor alpha (ERalpha) resulted in suppression of cell growth via a caveolin-1 dependent mechanism.
the findings reported here demonstrated that patients with mutations in FASN (c.G7192T, p.A2398S) and APOBR (c.C1883G, p.T628R) may be predisposed to hypothyroidism. These mutations may disrupt the regulation of fatty acid biosynthesis and lipid metabolism. These findings may reveal the high degree of genetic heterogeneity in hypothyroidism phenotypes.
Evaluation of FAS/FASL polymorphisms can predict lack of response to BCG immunotherapy and prevent the loss of valuable time before such alternative treatments as early cystectomy are initiated.
FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma.
HIV-1 infection increases intracellular levels of fatty acid synthase (FASN). Despite the requirement of FASN for nascent virion production, FASN activity was not required for intracellular Gag protein production, indicating that FASN dependent de novo fatty acid biosynthesis contributes to a late step of HIV-1 replication
Findings showed that FASN is upregulated in colorectal cancer cell lines that overexpress PGC-1alpha and indicated that FASN expression may enhance cancer cell proliferation by regulating antioxidant enzyme production and resistance to ROS-induced apoptosis. Further data provided evidence that FASN expression was regulated indirectly by PGC-1alpha.
Repression of FAS mRNA expression is the consequence of feedback inhibition of FAS expression by long chain fatty acyl-CoAs, which are formed by FACL3 during its upregulation by vitamin D3 in prostate cancer cells.
analysis of the expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx
Fatty acid synthase (FASN) mRNA and protein overexpression were associated with unfavorable clinicopathologic factors and poor outcomes.
KRAS is associated with activation of ERK2, induction of FASN, and promotion of lipogenesis.
The study has shown that the high frequency of FASN expression in intraepithelial neoplasia (hPIN)and cancer and no expression in most structures of benign hyperplasia make it possible to use this protein as an additional marker in the differential diagnosis of prostatic neoplasms.
FASN inhibition/knockdown significantly increased the susceptibility of cisplatin-resistant cells to NK cell cytotoxicity.
FASN has a role in leucine deprivation-inhibited proliferation and apoptosis of human breast cancer cells
HER2-FASN lipogenic axis delineates a group of breast cancer patients that might benefit from treatment with therapeutic regimens containing FASN inhibitors
FASN expression is down-regulated by miR-15a and miR-16-1 in breast cancer cells, regulating cell proliferation.
These findings implicate Spot14 as a direct protein enhancer of FASN catalysis in the mammary gland during lactation when maximal MCFA production is needed.
We found that FAS knockout caused excessive production of reactive oxygen species (ROS). Excess ROS induced ER stress, resulting in activation of the adaptive unfolded protein response (UPR). FAS knockout caused splicing of the X-box binding protein 1 gene (XBP1) and expression of spliced XBP1 mRNA.
FASN gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition
In this study, we investigated the FASN gene expression pattern and corresponding DNA methylation status in the inner layer of backfat from Jinhua pigs at different developmental stages.
calculated a 4.5 angstrom-resolution map of fatty acid synthase, and placed homologous template structures of all individual catalytic domains responsible for the cyclic elongation of fatty acid chains into the electron density
study determined fatty acid synthase crystal structure at 3.2 angstrom resolution covering five catalytic domains; structure reveals a complex architecture of alternating linkers and enzymatic domains
FASN is essential for TGF-beta signaling in pulmonary fibrosis.
an unexpected link between FASN and cholesterol synthesis that appears to be required for TLR signal transduction and proinflammatory macrophage activation.
FASN regulates the pathogenicity of Th17 cells.
genetic deletion of FASN totally suppresses hepatocarcinogenesis driven by AKT and AKT/c-Met protooncogenes in mice.
Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states.
study demonstrates that co-activation of AKT and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN pathway.
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
These findings suggest that activation of TSHR directly inhibits FASN expression in mature adipocytes, possibly mediated by PKA and ERK
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
FASN plays an important role in exercise-mediated cognitive enhancement, which might be associated to its role in modulating exercise-induced stimulation of neurogenesis.
FASN is essential for the development, functional competence, and maintenance of the lactating mammary gland.
Gamma-tocotrienol showed attenuation of triglyceride through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1, stearoyl CoA desaturase 1, and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6 cells.
Upregulation of host hepatic fatty acid synthase correlates with hepatitis B virus replication.
In vivo studies using germline (Creb1(-/-) ) and lung epithelial-specific (Creb1(EpiDelta/Delta) ) Creb1 knockout mice showed strongly reduced Scd1, but not Fasn gene expression and protein levels in lung epithelial cells.
Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.
fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult neural stem and progenitor cells and conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis
Kr-pok (kidney cancer-related POZ domain and Kruppel-like protein) activates transcription of the FASN gene.
FAS deficiency blocked the generation of palmitoylated Mucin 2, which must be S-palmitoylated at its N terminus for proper secretion and function.
We observed that increased melanoma progression is associated with enhanced Cav-1 and FASN expression in tumors from HFD mice.
Fatty acid synthase modulates homeostatic responses to myocardial stress
FASN single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
g.841G>C SNP of FASN gene is associated with fatty acid composition in beef cattle.
Results indicate that Fatty acid synthase (FASN) may be used as a candidate gene affecting intramuscular fat content in Datong yaks.
It was suggested that two cattle breeds have an advantage in terms of genotype and haplotype distribution of the FASN gene; a single polymorphism might be a potential marker for breed discrimination.
study evaluated the contributions of polymorphisms of FASN and SCD genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations
The five exonic single nucleotide polymorphisms of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents.
Results suggest that SCD and FASN are strong candidate genes influencing fatty acid composition in beef cattle.
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
In ruminants, FASN may be regulated between the ratio between two transcripts. The small transcript is mostly produced in tissues with low fatty acid synthesis.
Polymorphisms within the FASN gene are associated with milk-fat content.
SNPs in the FASN gene are associated with variation in the fatty acid composition of adipose fat and milk fat.
The four exons in FASN that encode for the TE domain were sequenced, and three SNPs, AF285607:g.17924A>G, g.18663T>C and g.18727C>T, were identified.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
Results suggest that the mutations may contribute to the characteristic fatty acid composition of Japanese Black beef.
The results suggested that LXR regulates FASN promoter activity through direct interaction with the LXR response element as well as through increasing SREBP1 abundance.
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
fatty acid synthase
, fatty acid synthase Fas
, Fatty acid synthase Fas
, Fatty Acid SyNthase family member (fasn-1)
, fatty-acid synthase
, fatty-acid synthase II
, fatty-acid synthase fas
, fatty acid synthetase
, short chain dehydrogenase/reductase family 27X, member 1