Aperçu des produits pour anti-PIK3C3 (PIK3C3) Anticorps

Full name:: anti-Phosphoinositide-3-Kinase, Class 3 Anticorps (PIK3C3)

Chez www.anticorps-enligne.fr sont 179 Phosphoinositide-3-Kinase, Class 3 (PIK3C3) Anticorps de 20 de différents fournisseurs disponibles. De plus, nous expédions PIK3C3 Kits (9) et PIK3C3 Protéines (7) et beaucoup plus de produits pour cette protéine. Un total de 199 PIK3C3 produits sont actuellement listés.

Synonymes:: 5330434F23Rik, hVps34, im:7147158, Vps34, wu:fc13g06, wu:fz51e12, zgc:112016, zgc:113009

afficher tous les anticorps	Gène	GeneID	UniProt
	PIK3C3	5289	Q8NEB9
	PIK3C3	65052	O88763
	PIK3C3	225326	Q6PF93
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Pathways pertinentes pour anti-PIK3C3 Anticorps

Autophagy

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anti-PIK3C3 Anticorps mieux référencés

Human Polyclonal PIK3C3 Primary Antibody pour ICC, IF - ABIN259946 : Huang, Hou, Chen, Zhao, Yan, Zhang, Yang, Kogan, Chen: PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. dans Autophagy 2011 (PubMed)
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Human Polyclonal PIK3C3 Primary Antibody pour IF (p), IHC (p) - ABIN711686 : Wang, Liang, Lau, Du, Guo, Yan, Gan, Yan, Zhao, Gao, Koch, Ma: Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling. dans Autophagy 2017 (PubMed)

Plus d’anticorps contre PIK3C3 partenaires d’interaction

Human Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.
Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2 (Montrer NRBF2 Anticorps)), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 (Montrer NRBF2 Anticorps) is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure.
This study reveals NRBF2 (Montrer NRBF2 Anticorps) as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.
Atg38 and its human ortholog NRBF2 (Montrer NRBF2 Anticorps), accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6 (Montrer BECN1 Anticorps)-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1 (Montrer BECN1 Anticorps)-ATG14 (human), were characterized.
p300 (Montrer EP300 Anticorps)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Low VPS34 expression is associated with cancer.
Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway.
Vps34 has a previously unknown role in regulating Rab7 (Montrer RAB7B Anticorps) activity and late endosomal trafficking.
High expression of VPS34 promoted GRP78 (Montrer HSPA5 Anticorps) transcription by modulating ATF6 (Montrer ATF6 Anticorps). VPS34 could enhance GRP78 (Montrer HSPA5 Anticorps) protein stability.
These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling.

Pig (Porcine) Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs

Mouse (Murine) Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

In mouse liver, Vps34 inactivation mildly dampens autophagy, limiting substrate availability for mitochondrial respiration and reducing gluconeogenesis.
AP-1 (Montrer JUN Anticorps)/sigma1A (Montrer AP1S1 Anticorps)-ArfGAP1 (Montrer ARFGAP3 Anticorps)-Rabex-5 (Montrer RABGEF1 Anticorps) complex formation leads to more endosomal Rabex-5 (Montrer RABGEF1 Anticorps) and enhanced, Rab5 (Montrer RAB5A Anticorps)(GTP (Montrer AK3 Anticorps))-stimulated Vps34 PI3-kinase (Montrer PIK3CA Anticorps) activity, which is essential for multivesicular body endosome formation.
dendritic cells from Vps34-deficient mice have a partially activated phenotype, spontaneously produce cytokines, and exhibit enhanced activity of the classic MHC class I and class II antigen-presentation pathways and displayed a defect in the homeostatic maintenance of splenic CD8alpha(+) dendritic cells and in the capacity of these cells to cross-present cell corpse-associated antigens to MHC class I-restricted T cells.
Results demonstrate that Vps34 is essential for proper myelination by Schwann cells. Depletion of PI3P leads to enlarged late endosomal/lysosomal vacuoles and suppressed trafficking in Schwann cells. Suppressed endosomal trafficking likely causes changes in the abundance and post-translational modification of ErbB2 (Montrer ERBB2 Anticorps)/3, a signaling defect that may contribute to arrested myelination in Vps34 deficient nerves.
Phosphatidylinositol-3-phosphate is light-regulated, and Vps34 is essential for survival of retinal rod photoreceptor cells.
This study reveals NRBF2 (Montrer NRBF2 Anticorps) as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.
This study uncovers a dual role for Vps34 as a regulator of platelet production by megakaryocytes and as an unexpected regulator of platelet activation and arterial thrombus formation dynamics.
E. chaffeensis secretes Etf-1 (Montrer ETF1 Anticorps) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 (Montrer RAB5A Anticorps) and class III PtdIns3K, while avoiding autolysosomal killing.
p300 (Montrer NOTCH1 Anticorps)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Vps34 has a previously unknown role in regulating Rab7 (Montrer RAB7A Anticorps) activity and late endosomal trafficking.

PIK3C3 profil antigène

Antigen Summary

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis (By similarity).

Alternative names and synonyms associated with PIK3C3

phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) anticorps
phosphatidylinositol 3-kinase catalytic subunit type 3 L homeolog (pik3c3.L) anticorps
phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3) anticorps
phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3) anticorps
phosphatidylinositol 3-kinase catalytic subunit type 3 (Pik3c3) anticorps

5330434F23Rik anticorps
hVps34 anticorps
im:7147158 anticorps
Vps34 anticorps
wu:fc13g06 anticorps
wu:fz51e12 anticorps
zgc:112016 anticorps
zgc:113009 anticorps

Protein level used designations for PIK3C3

phosphoinositide-3-kinase, class 3 , phosphatidylinositol 3-kinase catalytic subunit type 3 , PI3K type 3 , PI3-kinase type 3 , ptdIns-3-kinase type 3 , phosphoinositide-3-kinase class 3 , catalytic phosphatidylinositol 3-kinase 3 , PtdIns-3-kinase type 3 , phosphatidylinositol 3-kinase p100 subunit , class 3 phosphoinositide-3-kinase , PI-3K Vps34p

GENE ID	SPECIES
100053039	Equus caballus
446671	Xenopus laevis
455385	Pan troglodytes
548346	Danio rerio
5289	Homo sapiens
503700	Sus scrofa
65052	Rattus norvegicus
490477	Canis lupus familiaris
534815	Bos taurus
225326	Mus musculus
100857877	Gallus gallus

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