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Human Polyclonal PRKAG3 Primary Antibody pour IHC (p), WB - ABIN391060
Fukuyama, Ohta, Okoshi, Suehara, Kizaki, Nakagawa: Hypoxia induces expression and activation of AMPK in rat dental pulp cells. dans Journal of dental research 2007
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Cow (Bovine) Polyclonal PRKAG3 Primary Antibody pour ELISA - ABIN451738
Costford, Kavaslar, Ahituv, Chaudhry, Schackwitz, Dent, Pennacchio, McPherson, Harper: Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle. dans PLoS ONE 2007
Alleles of 2 equine AMPK (Montrer PRKAA1 Anticorps) gamma subunit genes had no causative role in polysaccharide storage myopathy in horses
PRKAG3-230 may be associated with sporadic Wolff-Parkinson-White (WPW) syndrome in a Taiwanese population.
The mTOR (Montrer FRAP1 Anticorps) pathway was significantly associated with overall and estrogen receptor (Montrer ESR1 Anticorps)-negative (ER-) breast cancer risk (P = 0.003 and 0.03, respectively). PRKAG3 (Padj = 0.0018) and RPS6KA3 (Montrer RPS6KA3 Anticorps) (Padj = 0.061) were the leading genes for the associations with overall breast cancer risk and ER- breast cancer risk, respectively.
Data suggest different gamma-isoforms in AMPK (Montrer PRKAA1 Anticorps) can have different effects on enzyme activation; here, activation of AMPK (Montrer PRKAA1 Anticorps) by compound 991 is greater if AMPK (Montrer PRKAA1 Anticorps) contains PRKAG2 (Montrer PRKAG2 Anticorps) versus PRKAG1 (Montrer PRKAG1 Anticorps) or PRKAG3.
Low PRKAA2 (Montrer PRKAA2 Anticorps) expression is associated with follicular lymphoma.
Through the enhancement of skeletal muscle glucose uptake and increased mitochondrial content, the R225W mutation of the gene encoding AMP-activated protein kinase (AMPK (Montrer PRKAA2 Anticorps))gamma(3)may significantly enhance exercise performance.
Purification and characterization of truncated human AMPK alpha 2 (Montrer PRKAA2 Anticorps) beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells
identified for the first time a mutation in the skeletal muscle-specific (Montrer EIF3K Anticorps) regulatory gamma(3) subunit of AMPK (Montrer PRKAA1 Anticorps) in humans
data show that different mutations in gamma3 exert different effects on allosteric regulation of alpha2beta2gamma3 complex by AMP (Montrer APRT Anticorps), whereas we find no evidence for their role in regulating the level of phosphorylation of alpha2 by upstream kinases.
Genetic variability in PRKAG3 does not seem to have a major effect on glucose metabolism, but play a role in lipoprotein metabolism in humans.
Variants in genes for AMPKalpha2 (Montrer PRKAA2 Anticorps) and AMPKgamma3 were not associated with PCOS or its component traits.
Association between polymorphism in bovine PRKAG3 gene and milk production traits.
Activity of glycogen synthase without the allosteric activator glucose 6-phosphate was decreased in gain of function AMPKgamma3(R200Q) relative to all other genotypes
allelic frequencies of PRKAG3 in several pig breeds
The variation in the promoter region of the porcine PRKAG3 gene has associations with meat quality phenotypes, including traits which are influenced by glycolytic potential and muscle metabolism in a breed-dependent manner.
PRKAG3 mutation influences muscle characteristics and promotes an oxidative phenotype to a varying degree among muscles with different functions
increased rate of glycogen (Montrer GYS1 Anticorps) synthesis following exercise in pigs carrying the PRKAG3 mutation correlates with an increased signalling response of Akt (Montrer AKT1 Anticorps) and its substrate, AS160 (Montrer TBC1D4 Anticorps).
Genetic variation of PRKAG3 was studied in indigenous breeds of China.
the R225Q mutation of PRKAG3 is associated with higher basal AMPK (Montrer PRKAA1 Anticorps) activity and diminished AMP (Montrer TMPRSS5 Anticorps) dependence
findings suggest that the R200Q mutation results in a constitutively active enzyme, leading to hyperaccumulation of glycogen (Montrer GYS1 Anticorps) due to the increased influx of glucose
Data suggest that the AMPK (Montrer PRKAA1 Anticorps)-TBC1D4 (Montrer TBC1D4 Anticorps) signaling axis is likely mediating the improved muscle insulin (Montrer INS Anticorps) sensitivity after contraction/exercise and illuminates an important and physiologically relevant role of AMPK (Montrer PRKAA1 Anticorps) in skeletal muscle.
gamma3-AMPK (Montrer PRKAA1 Anticorps) down-regulation is a rapid physiological muscle response observed in mouse after running exercise or fasting, two situations leading to PPARbeta (Montrer PPARD Anticorps) activation.
AMPK (Montrer PRKAA1 Anticorps) acts as the primordial trigger for fasting- and exercise-induced adaptations in skeletal muscle and that activation of SIRT1 (Montrer SIRT1 Anticorps) and its downstream signaling pathways are improperly triggered in AMPK (Montrer PRKAA1 Anticorps)-deficient states.
Gamma3 subunit of AMPK (Montrer PRKAA1 Anticorps) is highly expressed in fast-twitch glycolytic skeletal muscle, and wild-type gamma3 functions in the regulation of alpha1 catalytic activity, but it is not associated with changes in muscle glycogen (Montrer GYS1 Anticorps) concentrations
functional studies of the protein kinase (Montrer CDK7 Anticorps), AMP (Montrer TMPRSS5 Anticorps)-activated, gamma 3 (AMPK3) isoform further support the close connection between glycogen (Montrer GYS1 Anticorps) content and exercise performance in skeletal muscle
AMPKg3 is involved in the coordinated transcription of genes critical for lipid and glucose metabolism in white glycolytic skeletal muscle.
analysis of transcriptional regulation in skeletal muscle of AMP-activated protein kinase (Montrer PRKAA2 Anticorps) gamma3 R225Q transgenic and knock-out mice
Expression of either wild type or mutant (R225Q) gamma3-subunit of AMPK (Montrer PRKAA1 Anticorps) results in increased glycogen (Montrer GYS1 Anticorps) concentrations in muscle, but the mechanisms underlying this alteration appear to be different.
AMPK (Montrer PRKAA1 Anticorps) heterotrimeric complexes containing the AMPKgamma(3) subunit may play a specific role in linking circadian oscillators and energy metabolism in skeletal muscle.
Basal and A-769662-mediated IL-6 (Montrer IL6 Anticorps) release provide evidence for a role of AMPK (Montrer PRKAA1 Anticorps) in the regulation of IL-6 (Montrer IL6 Anticorps) release from oxidative skeletal muscle.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.
5'-AMP-activated protein kinase subunit gamma-3
, AMP-activated protein kinase gamma 3 subunit
, protein kinase, AMP-activated, gamma 3 non-catatlytic subunit
, 5'-AMP-activated protein kinase gamma-3 non-catalytic subunit long form
, AMP-activated protein kinase gamma subunit
, protein kinase non-catalytic gamma subunit
, AMP-activated protein kinase, non-catalytic gamma-3 subunit
, AMP-activated protein kinase gamma 3
, AMPK-activated protein kinase gamma-3 subunit
, protein kinase, AMP-activated, gamma 3 non-catalytic subunit a
, protein kinase, AMP-activated, gamma 3 non-catalytic subunit
, AMP-activated protein kinase subunit gamma
, 5'-AMP-activated protein kinase subunit gamma-3-like
, 5'-AMP-activated protein kinase, gamma-3 subunit
, AMPK gamma-3 chain
, AMPK gamma3
, AMPK subunit gamma-3
, 5'-AMP-activated protein kinase gamma-3 subunit
, AMP-activated protein kinase gamma