Aperçu des produits pour anti-SLC2A4 (SLC2A4) Anticorps

Human Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

1. Neither a single exercise bout, nor 10 days of exercise training, increased adipose tissue GLUT4, in contrast with the increases observed in skeletal muscle GLUT4 expression.

2. SLC2A4, RBP4, PCK1, and PIK3R1 genes may be involved in the pathogenesis of GDM.

3. Arachidonic acid binds to PPAR-gamma2 to activate the expression of GLUT4 in the HepG2 cell line, showing an alternative insulin-independent activation of GLUT4.

4. Placental expression of at least three GLUT isoforms, i.e. GLUT-1, GLUT-4, and GLUT-9, may be involved in the intensification of intrauterine fetal growth in pregnancies complicated by gestational diabetes mellitus and pregnancy complicated by diabetes mellitus, type 1.

5. significantly higher peripheral blood mononuclear cell GLUT4 levels in conditioned athletes than in sedentary subjects

6. Autophagy and GLUT4 utilise similar proteins (SNAREs) which are used for exocytosis. PI3K and AMPK control both autophagy and GLUT4. [review]

7. Higher expression of GLUT-4 is associated with Oral Epithelial Dysplasia compared to Oral Squamous Cell Carcinoma.

8. Adipose tissue sirtuin 1 was related to insulin sensitivity. The relationship was still present after controlling for BMI, however, it disappeared after controlling for adipose tissue SLC2A4. Muscle sirtuin 1 was not related to insulin sensitivity.

9. Results showed that GLUT4 translocation is regulated by TBC1D15 affecting glucose uptake.

10. This review will summarize the effects of phytochemicals and their action on insulin signaling pathways accelerating GLUT4 translocation based on the current literature.

11. Our results demonstrate that IR is associated with high circulating RBP4 and that suppressed RBP4 adipose tissue expression is accompanied by reduced GLUT4 expression in HD. Renal transplantation or HDF are effective in lowering serum RBP4 levels.

12. Cell-autonomous adiposity results from increased cell surface GLUT4 due to ankyrin-B deficiency in humans and mice.

13. The authors show that insulin-stimulated Glut4-mediated glucose uptake requires PDPK1 phosphorylation of the kinase domain but not mTORC2 phosphorylation of the hydrophobic domain. Nonetheless, an intact hydrophobic domain is required for Glut4-mediated glucose uptake.

14. rs5435 was not associated with T1D in the Euro-Brazilian population.

15. Three polymorphisms (rs2654185, rs5415, and rs5417) in SLC2A4 were positively correlated with hip circumference and the rs2654185 locus was also positively associated with thigh circumference. Consumption of n-3 polyunsaturated fatty acids modifies associations between SCD, SLC2A4, and SREBF1 polymorphisms and anthropometric variables and metabolic phenotypes.

16. increased GLUT4 expression in oral squamous cell carcinoma patients was significantly associated with a poor overall survival (OS, P = 0.035) and recurrence-free survival (RFS, P = 0.001). Furthermore, the ectopic overexpression of GLUT4 in cell lines with low endogenous GLUT4 expression resulted in a significant increase in migratory ability both in vitro and in vivo

17. The results of the study confirmed the presence of GLUT-1, GLUT-4 and GLUT-9 proteins in the trophoblast from both, uncomplicated and diabetic pregnancies. In addition, insulin therapy may increase placental expression of GLUT-4 and GLUT-9, and partially GLUT-1, in women with pregestational and gestational diabetes mellitus.

18. our study has found that BMI, hypertension, myometrial invasion, pathological type, and Glut4 positive expression might be prognostic factors of EC [Endometrial cancer ]

19. Our work highlights the convenience and efficiency of this novel pH-sensitive fluorescent probe and reveals the new biological activity of staurosporine as an agonist for GLUT4 translocation and as an effective insulin additive analogue.

20. studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization.

Pig (Porcine) Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

1. Feed intake remains low whereas respiratory frequency and body temperature remain higher and expression of HSP90, CAT1, SGLT1 and GLUT4 increases in some tissues in pigs under chronic heat stress conditions.

2. TBC1D4, insulin receptor and GLUT4 showed altered expression in some tissues in pre-diabetic pigs.

3. analysis of time- and breed-specific expression patterns of GLUT2 and GLUT4, which highlight their potential as candidate genes for assessing adipose deposition and muscle development in pigs

4. Chronic elevated calcium blocks AMPK-induced GLUT-4 expression in skeletal muscle.

Horse (Equine) Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

1. Insulin resistance was associated with a significantly reduced total GLUT4 content in omental adipose tissue, without a change in content in other visceral or subcutaneous adipose sites.

2. There was a significant difference when pooled means for Glut-4 expression in muscle compared with adipose tissue from different anatomical sites.

Mouse (Murine) Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

1. translocation of Glucose transporter type 4 (GLUT4) was accelerated in the skeletal muscle of IL-15 transgenic mice

2. BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARgamma and GLUT4 upregulation

3. Oral administration of AEG to adult diabetic mice increased NO, insulin and Glut-4 synthesis in the hepatocytes.

4. Results provide evidence that ABCA1 knockdown prevents Insulin-dependent GLUT4 translocation.

5. (E)-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone may increase glucose uptake by stimulating GLUT4 translocation to the plasma membrane.

6. beta-catenin is a previously unrecognized regulator of the mechanisms that control the insulin sensitive pool of GLUT4 transporters inside these adipocyte cells.

7. The study shows a novel role of leptin-induced P2X7r in modulating Glut4 induction and translocation in hepatic stellate cells, that are key to nonalcoholic steatohepatitis progression.

8. ESR1 activation in adipocytes increased the nuclear content of SP1 protein, the SP1/ESR1 interaction and SP1 binding into the Slc2a4 gene promoter, culminating with increased Slc2a4/GLUT4 expression

9. Those findings provide new insight into the mechanisms responsible for AMPKalpha2-dependent regulation of GLUT4 transcription after exercise.

10. Portulaca oleracea L. extract enhanced glucose uptake, which was caused by increased GLUT4 expression at the plasma membrane through activating the PI3K/Akt pathway.

11. 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine retains cell surface GLUT4 by suppressing PKC alpha-driven endocytic internalization of GLUT4, to enhance glucose uptake into cells and restrict an increase in the blood glucose levels after glucose loading in type 2 Diabetes Mellitus.

12. The data, therefore, suggest that 1,25(OH)2D3 increases glucose consumption by inducing SIRT1 activation, which in turn increases IRS1 phosphorylation and GLUT4 translocation in myotubes.

13. Cell-autonomous adiposity results from increased cell surface GLUT4 due to ankyrin-B deficiency in humans and mice.

14. G4+/- offspring on a High Fat Diet displayed early hypertension associated with increased renal gene expression of renin and the AT1- receptors compared to G4+/- on a C diet. This group showed decreased cardiac expression of key genes involved in fatty acid oxidation compared to WT on a C diet.

15. dynamin is a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis

16. Insulin-stimulated translocation of GLUT4 and GLUT8 was down-regulated in the atria of insulin resistance animals, as well as their total protein expression.

17. The disruption of SM22alpha enhances PDGF-BB-induced GLUT4 translocation and glucose uptake by promoting actin dynamics and cortical actin polymeriza- tion.

18. Data suggest that Glut4 expression is glucose-dependent in white adipocytes; low glucose availability reduces total NADH/NADPH levels; high glucose availability up-regulates total NADH/NADPH levels, promotes adipogenesis and lipogenesis, and induces Glut4 expression.

19. Glucose transporter 4 (GLUT4) is required for myocardial adaptations to exercise, and its absence accelerates heart dysfunction after pressure overload.

20. Data show that TBK1 directly interacts with Exo84 through the coiled-coil domain of TBK1 and helical domain of Exo84, and knockdown of TBK1 blocked insulin-stimulated glucose uptake and GLUT4 translocation.

Cow (Bovine) Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

1. Low GLUT1 and GLUT3 expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin responsive.

2. Results of the present study suggest that myostatin inhibits the expression of GLUT4 mRNA and that the greater ability of double muscled cattle to produce muscle may be due to their greater sensitivity to insulin and greater use of glucose.

3. GLUT4 gene expression increased during late lactation.

Goat Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) interaction partners

1. These results suggest that goat GLUT4 functions in the transport of glucose and it may play a positive role in amino acid uptake in mammary glands.