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Reticulon 4 (RTN4) (N-Term) anticorps Primary Antibody

RTN4 Reactivité: Humain, Souris, Rat IHC, ELISA, WB Hôte: Lapin Polyclonal
Pubmed (4)
N° du produit ABIN1002923
$513.04
Plus shipping costs $45.00
100 μg
local_shipping Destination: Etats-Unis
Envoi sous 15 à 19 jours ouvrables
  • Antigène
    Épitope
    N-Term
    Reactivité
    Humain, Souris, Rat
    Hôte
    Lapin
    Clonalité
    Polyclonal
    Conjugué
    Inconjugué
    Application
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Blocking Peptide
    Blocking peptide for this product available: ABIN1004166
    Purification
    Affinity chromatography purified via peptide column.
    Immunogène
    NogoA antibody was raised in rabbits against a 23 amino acid peptide from near the amino terminus of human NogoA.
    Isotype
    IgG
  • Antigène
    Autre désignation
    NogoA (RTN4 Antibody Extrait)
    Sujet
    NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients. Despite its predicted molecular weight, NogoA typically migrates at 180kDa in an SDS-PAGE. At least five isoforms of Nogo are known to exist, this antibody is specific for NogoA.
    Pathways
    Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome
  • Indications d'application
    NogoA antibody can be used for detection of NogoA by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Antibody is supplied in PBS containing 0.02% sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
    Stock
    4 °C
    Date de péremption
    12 months
  • Yan, Shi, Hu, Zhou: "Reticulon proteins: emerging players in neurodegenerative diseases." dans: Cellular and molecular life sciences : CMLS, Vol. 63, Issue 7-8, pp. 877-89, 2006 (PubMed).

    Schweigreiter, Bandtlow: "Nogo in the injured spinal cord." dans: Journal of neurotrauma, Vol. 23, Issue 3-4, pp. 384-96, 2006 (PubMed).

    Dupuis, Gonzalez de Aguilar, di Scala, Rene, de Tapia, Pradat, Lacomblez, Seihlan, Prinjha, Walsh, Meininger, Loeffler: "Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis." dans: Neurobiology of disease, Vol. 10, Issue 3, pp. 358-65, 2002 (PubMed).

    Chen, Huber, van der Haar, Frank, Schnell, Spillmann, Christ, Schwab: "Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1." dans: Nature, Vol. 403, Issue 6768, pp. 434-9, 2000 (PubMed).

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