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MAPKAP Kinase 2 anticorps (AA 310-325)

MAPKAPK2 Reactivité: Humain WB, IHC, ELISA, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN103960
  • Antigène Voir toutes MAPKAP Kinase 2 (MAPKAPK2) Anticorps
    MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
    Épitope
    • 39
    • 25
    • 19
    • 16
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 310-325
    Reactivité
    • 109
    • 95
    • 95
    • 21
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 133
    • 7
    • 2
    Lapin
    Clonalité
    • 119
    • 23
    Polyclonal
    Conjugué
    • 60
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Cet anticorp MAPKAP Kinase 2 est non-conjugé
    Application
    • 90
    • 42
    • 40
    • 39
    • 32
    • 24
    • 19
    • 12
    • 9
    • 8
    • 8
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)
    Attributs du produit
    Concentration Definition: by UV absorbance at 280 nm
    Stérilité
    Sterile filtered
    Immunogène
    Immunogen: This antibody was affinity purified from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to aa 310-325 of rabbit MAPKAP Kinase 2 conjugated to KLH using maleimide. A terminal cysteine residue was added to facilitate coupling.
    Isotype
    IgG
    Top Product
    Discover our top product MAPKAPK2 Anticorps primaire
  • Indications d'application
    This antibody is suitable for western blotting, ELISA, immunoprecipitation and kinase assays.  Although not tested, this antibody is likely functional in immunohistochemistry and other immunological methods. The antibody detects a single 44 kDa protein in crude extracts prepared either from unstimulated (p/n w09-000-364) or TNFα stimulated ((p/n w09-000-367) human HeLa cell lysates. A 1:15,000 dilution is recommended for ELISA. The researcher should determine optimal titers for other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.9 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
    Autre désignation
    MAPKAP Kinase 2 (MAPKAPK2 Produits)
    Synonymes
    anticorps mapkapk2, anticorps wu:fb30e10, anticorps wu:fc56c10, anticorps wu:fi03a01, anticorps MGC78852, anticorps MAPKAPK2, anticorps AA960234, anticorps MAPKAP-K2, anticorps MK-2, anticorps MK2, anticorps Rps6kc1, anticorps mitogen-activated protein kinase-activated protein kinase 2a, anticorps mitogen-activated protein kinase-activated protein kinase 2 L homeolog, anticorps mitogen-activated protein kinase-activated protein kinase 2, anticorps MAP kinase-activated protein kinase 2, anticorps mapkapk2a, anticorps mapkapk2.L, anticorps MAPKAPK2, anticorps Mapkapk2
    Sujet
    MAPKAP kinase-2 (or MK2) is an acronym for mitogen-activated protein kinase-activated protein kinase-2. This enzyme is phosphorylated and activated by Erks and p38 MAPK in vitro. While multiple residues of MK2 are phosphorylated in vivo in response to stress, only four of the residues Thr25, Thr222, Ser272 and Thr334 are phosphorylated by p38 in an in vitro kinase assay.  MK2 is serine-threonine protein kinase that contains a proline rich sequence and two putative SH3-binding sites.  MK2 phosphorylates downstream components on a consensus Pro-X-Ser/Thr-Pro motif. The best-characterized MK2 substrate is hsp27. Although unknown, the physiological function of MK2 may be to increase stress resistance.  MK2 is an essential component in the inflammatory response that regulates biosynthesis of TNFα at a post-transcriptional level and MK2 is rapidly phosphorylated and activated in response to cytokines, stress and chemotactic factors.
    Synonyms: MAPKAP kinase-2, MK2, mitogen-activated protein kinase-activated protein kinase-2
    ID gène
    9261
    UniProt
    P49137
    Pathways
    Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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