ROBO1 anticorps (AA 1632-1644)

N° du produit ABIN1043879

Détail du produit anti-ROBO1 anticorps

Antigène: ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))

Épitope: AA 1632-1644

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROBO1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Réactivité croisée: Souris, Rat (Rattus), Chien

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1632-1644 of Human ROBO-1.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA , IP, immunohistochemistry, immunofluorescence, and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~181 kDa in size corresponding to ROBO-1 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ROBO1 (ABIN1043879)

Li, Wang, Chen, Liang: "[Auditory neuropathy in children(analysis of 14 cases)]." dans: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, Vol. 19, Issue 1, pp. 19-21, (2006) (PubMed).

Détails sur ROBO1

Antigène: ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))

Autre désignation: ROBO-1 (ROBO1 Produits)

Synonymes: anticorps DUTT1, anticorps SAX3, anticorps AW494633, anticorps AW742721, anticorps Gm310, anticorps ROBO1, anticorps dutt1, anticorps roundabout, anticorps sax3, anticorps MGC122264, anticorps roundabout-1, anticorps roundabout guidance receptor 1, anticorps roundabout, axon guidance receptor, homolog 1 (Drosophila), anticorps roundabout guidance receptor 1 L homeolog, anticorps ROBO1, anticorps Robo1, anticorps robo1, anticorps robo1.L

Sujet: ROBO-1 (also called Roundabout homolog 1 precursor and Deleted in U twenty twenty (DUTT)) functions as a receptor for SLIT1 and SLIT2.  The SLIT proteins are thought to act as a molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex.  ROBO-1 may also be required for lung development. ROBO-1 is a type I membrane protein.  ROBO-1 is a widely expressed protein with the exception of the kidney.  Defects in ROBO1 may be a cause of breast and lung cancer. ROBO-1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. Multiple splice variants have been identified for this protein.
Synonyms: ROBO-1, Roundabout homolog 1 precursor, Deleted in U twenty twenty (DUTT)

ID gène: 6091

UniProt: Q2M1J3

Pathways: Positive Regulation of Endopeptidase Activity