Prosaposin anticorps (AA 325-524)

N° du produit ABIN1098150

Détail du produit anti-Prosaposin anticorps

Antigène: Prosaposin (PSAP)

Épitope: AA 325-524

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Prosaposin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purification: purified

Immunogène: Purified recombinant fragment of human PSAP (AA: 325-524 ) expressed in E. coli.

Clone: 4D5F4

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:50-1:500, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-Prosaposin (ABIN1098150)

Xu, Deng, Mao, Zhang, Wang, Wang, Mu, Deng, Ma: "The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." dans: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).

Hu, Delorme, Liu, Liu, Velasco-Gonzalez, Garai, Pullikuth, Koochekpour: "Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion." dans: Molecular cancer, Vol. 9, pp. 30, (2010) (PubMed).

Détails sur Prosaposin

Antigène: Prosaposin (PSAP)

Autre désignation: PSAP (PSAP Produits)

Synonymes: anticorps GLBA, anticorps SAP1, anticorps AI037048, anticorps SGP-1, anticorps SGP1A, anticorps cb759, anticorps wu:fa14a06, anticorps wu:fb36e02, anticorps wu:fb58g07, anticorps PSAP, anticorps PSP-A, anticorps SFTPA1B, anticorps SP-A, anticorps prosaposin, anticorps surfactant protein A1, anticorps PSAP, anticorps Psap, anticorps psap, anticorps LOC100011417, anticorps LOC100304726, anticorps LOC100526719, anticorps SFTPA1

Sujet:

Description: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. , ,

Aliases: GLBA, SAP1

Poids moléculaire: 58.1 kDa

ID gène: 5660

HGNC: 5660

Pathways: Positive Regulation of Endopeptidase Activity