ACD anticorps (C-Term)

N° du produit ABIN1105208

Détail du produit anti-ACD anticorps

Antigène: ACD (Adrenocortical Dysplasia Homolog (ACD))

Épitope: C-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACD est non-conjugé

Application: Western Blotting (WB)

Séquence: PRTSAQELCS VWEPPERHRD TSAFQYKYET PSASLHTQVQ TARLSPQLVA

Réactivité croisée (Details): Species reactivity (expected):RatSpecies reactivity (tested):Mouse

Purification: Purified using peptide immunoaffinity column

Immunogène: Synthetic peptide directed towards the c terminal of mouse Acd

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur ACD

Antigène: ACD (Adrenocortical Dysplasia Homolog (ACD))

Autre désignation: ACD (ACD Produits)

Synonymes: anticorps PIP1, anticorps PTOP, anticorps TINT1, anticorps TPP1, anticorps ACD, anticorps ACD, shelterin complex subunit and telomerase recruitment factor, anticorps adrenocortical dysplasia, anticorps ACD, anticorps Acd

Sujet: Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo.Synonyms: Adrenocortical dysplasia protein homolog, PIP1, PTOP, TINT1, TPP1

ID gène: 497652

NCBI Accession: NM_001012638

Pathways: Telomere Maintenance