Angiopoietin 2 anticorps (C-Term)

N° du produit ABIN1105366

Détail du produit anti-Angiopoietin 2 anticorps

Antigène: Angiopoietin 2 (ANGPT2)

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Angiopoietin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Séquence: Sequence is different from the related Mouse sequence by two amino acids.

Specificité: This antibody detects Angiopoietin-2 near C-term. No cross reactivity with other proteins.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide corresponding to a sequence mapping near the C-terminal of Human Angiopoietin-2

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium Azide, 5 mg BSA

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Angiopoietin 2

Antigène: Angiopoietin 2 (ANGPT2)

Autre désignation: Angiopoietin-2 (ANGPT2 Produits)

Synonymes: anticorps AGPT2, anticorps ANG2, anticorps Agpt2, anticorps Ang-2, anticorps Ang2, anticorps ang2, anticorps angpt2, anticorps ANGIOPOIETIN-2, anticorps ANG-2, anticorps ANGPT2, anticorps Angrp, anticorps Rnase5b, anticorps ANG3, anticorps C11orf2, anticorps C11orf3, anticorps FFR, anticorps angiopoietin 2, anticorps angiopoietin 2b, anticorps angiogenin, ribonuclease A family, member 2, anticorps VPS51, GARP complex subunit, anticorps ANGPT2, anticorps Angpt2, anticorps angpt2b, anticorps Ang2, anticorps VPS51

Sujet: Angiopoietin 1 and Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2. Angiopoietin 2 is only 60 % homologous with Angiopoietin 1. Angiopoietin-2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation. Angiopoietin 1 binding to Tie 2 causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.Synonyms: ANG-2, ANG2, ANGPT2

ID gène: 11601

NCBI Accession: NP_031452

UniProt: O35608

Pathways: Signalisation RTK