EYA3 anticorps (Middle Region)

N° du produit ABIN1107155

Détail du produit anti-EYA3 anticorps

Antigène: EYA3 (Eyes Absent Homolog 3 (EYA3))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EYA3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Séquence: QSRKNMTSKN RGKRKADATS SQDSELERVF LWDLDETIII FHSLLTGSYA

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, DogSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogène: The immunogen for anti-EYA3 antibody: synthetic peptide directed towards the middle region of human EYA3.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur EYA3

Antigène: EYA3 (Eyes Absent Homolog 3 (EYA3))

Autre désignation: EYA3 (EYA3 Produits)

Synonymes: anticorps zgc:152966, anticorps si:ch211-195b13.2, anticorps Xeya3, anticorps MGC85199, anticorps EYA3, anticorps AI844637, anticorps EYA transcriptional coactivator and phosphatase 3, anticorps EYA transcriptional coactivator and phosphatase 3 L homeolog, anticorps eya3, anticorps eya3.L, anticorps EYA3, anticorps Eya3

Sujet: EYA3 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. This protein promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. EYA3 coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity.Synonyms: Eyes absent homolog 3

ID gène: 2140

NCBI Accession: NP_001981

Pathways: Positive Regulation of Response to DNA Damage Stimulus