SLC25A4
Reactivité: Humain
Hôte: Lapin
Polyclonal
FITC
Indications d'application
ELISA: 1/500-1/2000. Western blot: Gives A peptide blockable duplet at 31/33 kD in rat heart mitochondria. Alsopart peptide blockable duplets at 38/48 and 66/70 kD. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Concentration
5.0 mg/mL (by OD280)
Buffer
PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Antigène
SLC25A4
(Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 4 (SLC25A4))
anticorps 1, anticorps AAC1, anticorps ANT, anticorps ANT 1, anticorps ANT1, anticorps PEO2, anticorps PEO3, anticorps T1, anticorps AU019225, anticorps Ant1, anticorps ant, anticorps ant1, anticorps peo2, anticorps peo3, anticorps MANT1, anticorps SLC25A5, anticorps fa22e07, anticorps wu:fa22e07, anticorps zgc:77591, anticorps slc25a4, anticorps solute carrier family 25 member 4, anticorps solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4, anticorps adenine nucleotide translocator, anticorps solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4, anticorps solute carrier family 25 member 4 L homeolog, anticorps SLC25A4, anticorps Slc25a4, anticorps slc25a4, anticorps ANT1, anticorps slc25a4.L
Sujet
Adenine Nucleotide Translocase 1 (ANT1) catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. It is is a key component of the mitochondrial permeability transition pore (PT pore) complex and is also one of the most abundant proteins in the mitochondrion making up approximately 10 % of all mitochondrial proteins. Originally described as an ADP/ATP exchange factor, ANT1 has also been shown to be required for bax mediated apoptosis. This is effected by binding of bax to residues 105-156 of ANT1, presumably resulting in maintaining the PT pore in an open conformation. Interaction with bax is not required for ANT1 pro-apoptotic activity as overexpression of the ANT1 protein also leads to the induction of apoptosis.Synonyms: ADP/ATP translocase 1, ANT 1, Adenine nucleotide translocator 1, Solute carrier family 25 member 4