NLRP3 anticorps (Pyrin Domain)

N° du produit ABIN1169100

Détail du produit anti-NLRP3 anticorps

Highlights:

• NLRP3 antibody for reliable recognition of mouse and human NLRP3/NALP3
• This un-conjugated monoclonal antibody has 60 PubMed citations

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Épitope: AA 1-93, Pyrin Domain

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NLRP3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificité: Recognizes mouse and human NLRP3/NALP3.

Réactivité croisée: Humain, Souris

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse NLRP3/NALP3 (pyrin domain) (aa 1-93).

Clone: Cryo-2

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-NLRP3 (ABIN1169100)

Zhu, Tang: "LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression." dans: Bioscience reports, Vol. 40, Issue 8, (2020) (PubMed).

Wong, Lewis, Doherty, Shi, Cashikar, Amelianchik, Tymchuk, Sullivan, Qian, Covey, Petsko, Holtzman, Paul, Luo: "25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner." dans: Journal of neuroinflammation, Vol. 17, Issue 1, pp. 192, (2020) (PubMed).

Hoyle, Redondo-Castro, Cook, Tzeng, Allan, Brough, Lemarchand: "Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture." dans: Immunology, Vol. 161, Issue 1, pp. 39-52, (2020) (PubMed).

Shrivastava, Visoso-Carvajal, Garcia-Cordero, Leon-Juarez, Chavez-Munguia, Lopez, Nava, Villegas-Sepulveda, Cedillo-Barron: "Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome." dans: Frontiers in immunology, Vol. 11, pp. 352, (2020) (PubMed).

Wang, Hu, Wu, Feng, Li, Liu, Wang, Chen, Tian, Xiao, Zhang, Shereen, Chen, Pan, Wan, Wu, Wu: "STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection." dans: PLoS pathogens, Vol. 16, Issue 3, pp. e1008335, (2020) (PubMed).

Lai, Hsu, Lee, Chiang: "Microtubule-Mediated NLRP3 Inflammasome Activation Is Independent of Microtubule-Associated Innate Immune Factor GEF-H1 in Murine Macrophages." dans: International journal of molecular sciences, Vol. 21, Issue 4, (2020) (PubMed).

Wooff, Fernando, Wong, Dietrich, Aggio-Bruce, Chu-Tan, Robertson, Doyle, Man, Natoli: "Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration." dans: Scientific reports, Vol. 10, Issue 1, pp. 2263, (2020) (PubMed).

Svensson, Andersson, Manouchehrian, Yang, Deierborg: "Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer's disease." dans: Scientific reports, Vol. 10, Issue 1, pp. 1346, (2020) (PubMed).

Cai, Ge, Mennone, Hoque, Ouyang, Boyer: "Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse." dans: Cellular and molecular gastroenterology and hepatology, Vol. 9, Issue 4, pp. 679-688, (2020) (PubMed).

Dionísio, Oliveira, Gaspar, Gama, Castro-Caldas, Amaral, Rodrigues: "Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson's disease." dans: Cell death & disease, Vol. 10, Issue 11, pp. 840, (2020) (PubMed).

Du, Lu, Wang, Ding, Wu, Hu: "The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3." dans: Experimental & molecular medicine, Vol. 51, Issue 8, pp. 1-13, (2020) (PubMed).

Hoss, Mueller, Rojas Ringeling, Rodriguez-Alcazar, Brinkschulte, Seifert, Stahl, Broderick, Putnam, Kolodner, Canzar, Geyer, Hoffman, Latz: "Alternative splicing regulates stochastic NLRP3 activity." dans: Nature communications, Vol. 10, Issue 1, pp. 3238, (2020) (PubMed).

Sharif, Wang, Wang, Magupalli, Andreeva, Qiao, Hauenstein, Wu, Núñez, Mao, Wu: "Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome." dans: Nature, Vol. 570, Issue 7761, pp. 338-343, (2020) (PubMed).

Xue, Xi, Liu, Guo, Zhang, Zhang, Li, Yang, Zhou, Yang, Zhang, Zhang, Gu, Yang, Da, Yao, Duo, Zhang: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." dans: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).

Huang, Feng, Jiang, Li, Xiang, Guo, Yang, Fei, Guo, Zheng, Wu, Chen: "VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages." dans: Science advances, Vol. 5, Issue 1, pp. eaau7426, (2020) (PubMed).

Liu, Lu, Chen, Muthuraj, Li, Pattabiraman, Zempleni, Kachman, Natarajan, Yu: "Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice." dans: Nutrients, Vol. 12, Issue 2, (2020) (PubMed).

Deng, Guo, Tam, Johnson, Brickey, New, Lenox, Shi, Golenbock, Koller, McKinnon, Beutler, Ting: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." dans: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).

Sanchez-Lopez, Zhong, Stubelius, Sweeney, Booshehri, Antonucci, Liu-Bryan, Lodi, Terkeltaub, Lacal, Murphy, Hoffman, Tiziani, Guma, Karin: "Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production." dans: Cell metabolism, Vol. 29, Issue 6, pp. 1350-1362.e7, (2020) (PubMed).

Kiyohara, Sujino, Teratani, Miyamoto, Arai, Nomura, Harada, Aoki, Koda, Mikami, Mizuno, Naganuma, Hisamatsu, Kanai: "Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells." dans: Cellular and molecular gastroenterology and hepatology, Vol. 7, Issue 1, pp. 135-156, (2019) (PubMed).

Hafner-Bratkovič, Sušjan, Lainšček, Tapia-Abellán, Cerović, Kadunc, Angosto-Bazarra, Pelegrin, Jerala: "NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway." dans: Nature communications, Vol. 9, Issue 1, pp. 5182, (2019) (PubMed).

Détails sur NLRP3

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Autre désignation: NLRP3/NALP3 (NLRP3 Produits)

Synonymes: anticorps CIAS1, anticorps Nalp3, anticorps avp, anticorps cias1, anticorps nalp3, anticorps pypaf1, anticorps agtavprl, anticorps AGTAVPRL, anticorps AII, anticorps AVP, anticorps C1orf7, anticorps CLR1.1, anticorps FCAS, anticorps FCU, anticorps MWS, anticorps NALP3, anticorps PYPAF1, anticorps AII/AVP, anticorps Cias1, anticorps Mmig1, anticorps Pypaf1, anticorps NLR family pyrin domain containing-like, anticorps NLR family pyrin domain containing 3, anticorps NLR family, pyrin domain containing 3 L homeolog, anticorps NLR family, pyrin domain containing 3, anticorps NLRPL, anticorps NLRP3, anticorps nlrp3.L, anticorps Nlrp3

Sujet: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

UniProt: Q8R4B8

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome