NLRP3 anticorps (Pyrin Domain)

N° du produit ABIN1169101

Détail du produit anti-NLRP3 anticorps

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Épitope: AA 1-93, Pyrin Domain

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NLRP3 est non-conjugé

Application: Western Blotting (WB)

Specificité: Recognizes mouse NLRP3/NALP3.

Réactivité croisée: Souris

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse NLRP3/NALP3 (pyrin domain) (aa 1-93).

Clone: Cryo-1

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-NLRP3 (ABIN1169101)

Dey, Joshi, Oliveira, Pereira, Guimarães-Costa, Serafim, de Castro, Coutinho-Abreu, Bhattacharya, Townsend, Aslan, Perkins, Karmakar, Ismail, Karetnick, Meneses, Duncan, Nakhasi, Valenzuela, Kamhawi: "Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β." dans: Cell host & microbe, Vol. 23, Issue 1, pp. 134-143.e6, (2018) (PubMed).

Li, Ju, Hsieh, Dong, Chen, Hua, Chen: "A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP." dans: PLoS ONE, Vol. 12, Issue 7, pp. e0182057, (2017) (PubMed).

He, Wan, Hu, Chen, Wang, Huang, Yang, Zhong, Han: "Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion." dans: Cell research, Vol. 25, Issue 12, pp. 1285-98, (2016) (PubMed).

Dashdorj, Jyothi, Lim, Jo, Nguyen, Ha, Yoon, Kim, Park, Murphy, Kim: "Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines." dans: BMC medicine, Vol. 11, pp. 178, (2013) (PubMed).

Détails sur NLRP3

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Autre désignation: NLRP3/NALP3 (NLRP3 Produits)

Synonymes: anticorps CIAS1, anticorps Nalp3, anticorps avp, anticorps cias1, anticorps nalp3, anticorps pypaf1, anticorps agtavprl, anticorps AGTAVPRL, anticorps AII, anticorps AVP, anticorps C1orf7, anticorps CLR1.1, anticorps FCAS, anticorps FCU, anticorps MWS, anticorps NALP3, anticorps PYPAF1, anticorps AII/AVP, anticorps Cias1, anticorps Mmig1, anticorps Pypaf1, anticorps NLR family pyrin domain containing-like, anticorps NLR family pyrin domain containing 3, anticorps NLR family, pyrin domain containing 3 L homeolog, anticorps NLR family, pyrin domain containing 3, anticorps NLRPL, anticorps NLRP3, anticorps nlrp3.L, anticorps Nlrp3

Sujet: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

UniProt: Q8R4B8

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome