FOXP3 anticorps (Forkhead Box P3)

Details for Product anti-FOXP3 Antibody No. ABIN1169339
Antigène
  • foxp3
  • FOXP3
  • AIID
  • DIETER
  • IPEX
  • PIDX
  • XPID
  • JM2
  • scurfin
  • sf
  • RGD1562112
  • forkhead box P3
  • forkhead box P3a
  • forkhead box P3 L homeolog
  • FOXP3
  • foxp3a
  • foxp3
  • foxp3.L
  • Foxp3
Reactivité
Souris
317
208
68
41
11
7
4
3
3
2
2
1
1
1
Hôte
Rat
201
146
38
25
3
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp FOXP3 est non-conjugé
27
25
21
19
14
12
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
259
164
152
98
79
28
27
23
21
19
16
8
6
5
3
3
Options
Immunogène Recombinant mouse FOXP3.
Clone MF333F
Isotype IgG2a
Specificité Recognizes mouse FOXP3. Detects a band of ~46-49 kDa by Western blot.
 Réactivité croisée Souris
Stérilité 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others FOXP3 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation FOXP3 (FOXP3 Antibody Extrait)
Sujet FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.
UniProt Q99JB6
Pathways Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Agent conservateur Without preservative
Stock 4 °C,-20 °C
Stockage commentaire Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
Date de péremption 12 months
Images (Fournisseur)
Immunofluorescence (IF) image for anti-Forkhead Box P3 (FOXP3) antibody (ABIN1169339) Immunofluorescent imaging of activated mouse CD4+ T cells with anti-FOXP3 (mouse), mA...
Western Blotting (WB) image for anti-Forkhead Box P3 (FOXP3) antibody (ABIN1169339) Western blot analysis of mouse Foxp3 using anti-Foxp3 (mouse), mAb(MF333F) at 1:2,0...
Produit citée dans: Perone, Bertera, Shufesky, Divito, Montecalvo, Mathers, Larregina, Pang, Seth, Wucherpfennig, Trucco, Baum, Morelli: "Suppression of autoimmune diabetes by soluble galectin-1." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 5, pp. 2641-53, 2009 (PubMed).

Nanni, Nicoletti, Palladini, Croci, Murgo, Antognoli, Landuzzi, Fabbi, Ferrini, Musiani, Iezzi, De Giovanni, Lollini: "Antimetastatic activity of a preventive cancer vaccine." dans: Cancer research, Vol. 67, Issue 22, pp. 11037-44, 2007 (PubMed).

Turnquist, Raimondi, Zahorchak, Fischer, Wang, Thomson: "Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 11, pp. 7018-31, 2007 (PubMed).

Lan, Wang, Raimondi, Wu, Colvin, de Creus, Thomson: ""Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 9, pp. 5868-77, 2006 (PubMed).

Perone, Bertera, Tawadrous, Shufesky, Piganelli, Baum, Trucco, Morelli: "Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 8, pp. 5278-89, 2006 (PubMed).

Ambrosino, Spadaro, Iezzi, Curcio, Forni, Musiani, Wei, Cavallo: "Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance." dans: Cancer research, Vol. 66, Issue 15, pp. 7734-40, 2006 (PubMed).

Raimondi, Shufesky, Tokita, Morelli, Thomson: "Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2808-16, 2006 (PubMed).