FNDC5 anticorps

N° du produit ABIN1169430

Détail du produit anti-FNDC5 anticorps

Antigène: FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FNDC5 est non-conjugé

Application: Western Blotting (WB)

Specificité: Recognizes human, mouse, rat, monkey Irisin and FNDC5. Detects endogenous mouse and human Irisin [Lit: 1-2].

Réactivité croisée: Humain, Singe, Souris, Rat (Rattus)

Immunogène: Recombinant irisin.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-FNDC5 (ABIN1169430)

Wrann, White, Salogiannnis, Laznik-Bogoslavski, Wu, Ma, Lin, Greenberg, Spiegelman: "Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway." dans: Cell metabolism, Vol. 18, Issue 5, pp. 649-59, (2013) (PubMed).

Détails sur FNDC5

Antigène: FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))

Autre désignation: Irisin (FNDC5 Produits)

Synonymes: anticorps FRCP2, anticorps irisin, anticorps 1500001L03Rik, anticorps AI836596, anticorps C87088, anticorps PeP, anticorps Pxp, anticorps fndc5, anticorps si:dkey-264p5.1, anticorps zgc:158684, anticorps fibronectin type III domain containing 5, anticorps fibronectin type III domain containing 5b, anticorps FNDC5, anticorps Fndc5, anticorps fndc5b

Sujet: Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

UniProt: Q8NAU1

Pathways: Hormone Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation