PDGFRA anticorps

N° du produit ABIN1176995

Détail du produit anti-PDGFRA anticorps

Antigène: PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PDGFRA est non-conjugé

Application: Flow Cytometry (FACS)

Marque: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogène: Mouse PDGF Receptor alpha chain

Clone: APA5

Isotype: IgG2a kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Références pour anticorps anti-PDGFRA (ABIN1176995)

Fruttiger, Calver, Krüger, Mudhar, Michalovich, Takakura, Nishikawa, Richardson: "PDGF mediates a neuron-astrocyte interaction in the developing retina." dans: Neuron, Vol. 17, Issue 6, pp. 1117-31, (1997) (PubMed).

Takakura, Yoshida, Kunisada, Nishikawa, Nishikawa: "Involvement of platelet-derived growth factor receptor-alpha in hair canal formation." dans: The Journal of investigative dermatology, Vol. 107, Issue 5, pp. 770-7, (1996) (PubMed).

Heldin: "Structural and functional studies on platelet-derived growth factor." dans: The EMBO journal, Vol. 11, Issue 12, pp. 4251-9, (1992) (PubMed).

Détails sur PDGFRA

Antigène: PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

Autre désignation: CD140A (PDGFRA Produits)

Synonymes: anticorps AI115593, anticorps CD140a, anticorps Pdgfr-2, anticorps APDGFR, anticorps PDGFACE, anticorps CD140A, anticorps PDGFR-2, anticorps PDGFR2, anticorps RHEPDGFRA, anticorps PDGFR, anticorps PDGFR-A, anticorps platelet derived growth factor receptor alpha, anticorps platelet derived growth factor receptor, alpha polypeptide, anticorps platelet-derived growth factor receptor, alpha polypeptide L homeolog, anticorps platelet-derived growth factor receptor, alpha polypeptide, anticorps PDGFRA, anticorps Pdgfra, anticorps pdgfra.L

Sujet: The APA5 antibody monoclonal antibody specifically binds to the Platelet-Derived Growth Factor (PDGF) Receptor alpha chain (CD140a, PDGFR-a), a receptor tyrosine kinase that is widely expressed on cells of mesenchymal origin in the embryo and adult and on several other cell types during embryonic development, but not on hematopoietic cells. PDGFR-a binds to PDGF A and B chains, in contrast to PDGFR-b, that binds only to the PDGF B chain. Biologically active PDGF is a disulphide-linked dimer, forming the AA, AB, and BB isoforms. Ligand binding to the PDGF Receptor induces the formation of receptor dimers (aa, ab, or bb), autophosphorylation, and internalization. The APA5 antibody has been demonstrated to block binding of PDGF-AA to PDGFR-a-expressing cells in vitro and to block some PDGF-mediated developmental events in vivo.
Synonyms: Pdgfra, Pdgfr2, PDGF-R alpha, Platelet derived growth factor receptor alpha

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling