CD48 anticorps
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- Antigène Voir toutes CD48 Anticorps
- CD48
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Reactivité
- Souris
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Hôte
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Hamster arménien
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD48 est non-conjugé
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Application
- Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Blocking Reagent (BR)
- Marque
- BD Pharmingen™
- Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Stérilité
- 0.2 μm filtered
- niveau d'endotoxine
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- Immunogène
- Mouse T lymphoma MBL-2
- Clone
- HM48-1
- Isotype
- IgG1 lambda
- Top Product
- Discover our top product CD48 Anticorps primaire
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/mL
- Buffer
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- Agent conservateur
- Azide free
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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Identification of the 2B4 molecule as a counter-receptor for CD48." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 5809-12, (1998) (PubMed).
: "Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival." dans: The Journal of experimental medicine, Vol. 179, Issue 1, pp. 341-6, (1994) (PubMed).
: "CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation." dans: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1241-9, (1992) (PubMed).
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Identification of the 2B4 molecule as a counter-receptor for CD48." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 5809-12, (1998) (PubMed).
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- Antigène
- CD48
- Autre désignation
- CD48 (BCM1) (CD48 Produits)
- Synonymes
- anticorps AI449234, anticorps AW610730, anticorps BCM1, anticorps BLAST, anticorps BLAST-1, anticorps BLAST1, anticorps Bcm-1, anticorps MEM-102, anticorps SLAMF2, anticorps Sgp-60, anticorps hCD48, anticorps mCD48, anticorps CD48 antigen, anticorps Cd48 molecule, anticorps CD48 molecule, anticorps Cd48, anticorps CD48
- Sujet
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The HM48-1 monoclonal antibody specifically binds to CD48 (previously known as BCM1 in mice, Blast-1 in human, and OX-45 in the rat), a GPI-anchored member of the Ig superfamily. It is widely distributed on leukocytes, but not on non-hematopoietic cells, and its ligands include CD2 (LFA-2) and CD244 (2B4 antigen). The HM48-1 mAb blocks binding of soluble CD2 to CD48-bearing cells, blocks the interaction of CD2 and CD244, inhibits spleen cell proliferative responses to mitogens, augments the proliferative response of spleen cells when cross-linked with anti-CD3e mAbs, and inhibits priming of CTL in vitro. In vivo administration of HM48-1 antibody can prolong survival of cardiac allografts, an effect which is greatly enhanced by the addition of anti-CD2 mAb 12-15. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.
Synonyms: BLAST, BLAST-1, BCM1, HM48-1, MEM-102, Sgp-60, SLAMF2
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