CD226 anticorps
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- Antigène Voir toutes CD226 Anticorps
- CD226
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD226 est non-conjugé
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Application
- Flow Cytometry (FACS), Functional Studies (Func)
- Marque
- BD Pharmingen™
- Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Stérilité
- 0.2 μm filtered
- niveau d'endotoxine
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- Clone
- DX11
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD226 Anticorps primaire
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- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- Agent conservateur
- Azide free
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes." dans: Immunity, Vol. 4, Issue 6, pp. 573-81, (1996) (PubMed).
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DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes." dans: Immunity, Vol. 4, Issue 6, pp. 573-81, (1996) (PubMed).
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- Antigène
- CD226
- Autre désignation
- CD226 (CD226 Produits)
- Sujet
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Reacts with DNAX accessory molecule-1 (DNAM-1), a 65 kDa transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains. DNAM-1 is expressed on the majority of T cells, NK cells, monocytes, and a subset of B cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface CD3. DNAM-1 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. DNAM-1 is a tyrosinephosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. DX11 inhibits T- and NKcell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells.
Synonyms: DNAM-1 - Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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