ATF3 anticorps (AA 113-130)

N° du produit ABIN129602

Détail du produit anti-ATF3 anticorps

Antigène: ATF3 (Activating Transcription Factor 3 (ATF3))

Épitope: AA 113-130

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This antibody was produced from a synthetic peptide corresponding to aa 113-130 of human ATF3.

Isotype: IgG

Information d'application

Indications d'application: Affinity purified anti-ATF3 has been tested by ELISA and western blotting against recombinant forms of the protein. Although not tested, this antibody is likely function in most immunoassays including immunofluorescence microscopy, immunohistochemistry.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ATF3 (ABIN129602)

Xie, Xu, Wu, Shen, Zhao, Du, Lv, Gu, Pan, Xu, Xie, Li: "Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells." dans: The American journal of pathology, Vol. 176, Issue 2, pp. 939-51, (2010) (PubMed).

Détails sur ATF3

Antigène: ATF3 (Activating Transcription Factor 3 (ATF3))

Autre désignation: ATF3 (ATF3 Produits)

Synonymes: anticorps zgc:55526, anticorps ATF3, anticorps LRG-21, anticorps LRF-1, anticorps LRFI, anticorps atf-3, anticorps activating transcription factor 3, anticorps activating transcription factor 3 L homeolog, anticorps atf3, anticorps ATF3, anticorps Atf3, anticorps atf3.L

Sujet: ATF3, or Activating Transcription Factor 3, is a member of mammalian activation TF/CREB protein family of transcription factors. ATF3 binds the cAMP response element (cre) (consensus: 5'-gtgacgt[ac][ag]-3'), a sequence present in many viral and cellular promoters. However, ATF3 represses rather than activates transcription from promoters with ATF sites stabilizing inhibitory co-factors at the promoter.  Alternate splicing forms of ATF3, called ATF3 delta Zip, lack the leucine zipper domain and do not bind DNA.  ATF3 delta Zip stimulates transcription, presumably by sequestering inhibitory co-factors away from the promoter.  Human ATF3 (SwissProt 18847) is a 20575 Da protein composed of 181 amino acids.
Synonyms: Cyclic AMP-dependent transcription factor ATF-3 cAMP-dependent transcription factor ATF-3 Activating transcription factor 3

ID gène: 467

UniProt: P18847

Pathways: Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response