SPRY4 anticorps (AA 306-322)

N° du produit ABIN129626

Détail du produit anti-SPRY4 anticorps

Antigène: SPRY4 (Sprouty RTK Signaling Antagonist 4 (SPRY4))

Épitope: AA 306-322

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPRY4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Chimpanzé

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 306-322 of Human Sprouty-4 protein.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band (maybe a doublet) ~35 kDa in size corresponding to Sprouty-4 by western blotting in the appropriate cell lysate or extract.  Some non-specific banding may be observed using this antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.1 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur SPRY4

Antigène: SPRY4 (Sprouty RTK Signaling Antagonist 4 (SPRY4))

Autre désignation: Sprouty-4 (SPRY4 Produits)

Synonymes: anticorps SPRY4, anticorps LOC100218545, anticorps HH17, anticorps A030006O18Rik, anticorps sprouty4, anticorps sprouty RTK signaling antagonist 4, anticorps sprouty (Drosophila) homolog 4, anticorps sprouty homolog 4 (Drosophila), anticorps Spry4, anticorps SPRY4, anticorps spry4

Sujet: Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS.  SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine.
Synonyms: Sprouty-4, SPRY4

ID gène: 81848, 42741659

UniProt: P08183