SLIT2 anticorps (AA 484-500)

N° du produit ABIN129628

Détail du produit anti-SLIT2 anticorps

Antigène: SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))

Épitope: AA 484-500

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLIT2 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Poulet

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding aa 484-500 of Human SLIT-2 protein.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~ 165 kDa corresponding to full-length protein by western blotting in the appropriate cell lysate or extract.  For western blotting block the membrane with goat serum.  Do not block with non-fat dry milk.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur SLIT2

Antigène: SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))

Autre désignation: SLIT-2 (SLIT2 Produits)

Synonymes: anticorps SLIL3, anticorps Slit-2, anticorps Drad-1, anticorps E030015M03Rik, anticorps E130320P19Rik, anticorps Slil3, anticorps mKIAA4141, anticorps Slit, anticorps slil3, anticorps slit-2, anticorps slit2-a, anticorps SLIT2, anticorps slit guidance ligand 2, anticorps slit homolog 2 (Drosophila), anticorps slit guidance ligand 2 S homeolog, anticorps SLIT2, anticorps Slit2, anticorps slit2, anticorps slit2.S

Sujet: SLIT-2 is thought to act as a molecular guidance cue in cellular migration, and its function appears to be mediated by interaction with roundabout homologue receptors.  SLIT-1 and SLIT-2 seem to be essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development SLIT-2 may play a role in guiding commissural axons once they reach the floor plate by modulating the response to netrin.  In vitro, SLIT-2 silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex.  In vitro, only commissural axons that crossed the midline responded to SLIT-2.  In the developing visual system this protein functions as a repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm.  SLIT-2 is a secreted protein predominantly expressed in fetal lung and kidney, and adult spinal cord.  Weak expression is observed in adult adrenal gland, thyroid, trachea and other tissues examined.  Multiple isoforms have been reported for this product.
Synonyms: Drad-1 antibody, E030015M03Rik antibody, E130320P19Rik antibody, FLJ14420 antibody, Slil 3 antibody, Slil3 antibody

ID gène: 9353, 4759146

UniProt: O94813

Pathways: Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration