SCN2A anticorps (Sodium Channel, Voltage-Gated, Type II, alpha Subunit)

Details for Product anti-SCN2A Antibody No. ABIN1304839
Antigène
  • SCN2A2
  • 6430408L10
  • A230052E19Rik
  • Nav1.2
  • Scn2a
  • NachII
  • RII/RIIA
  • RNSCPIIR
  • SCN
  • SCN2A
  • Scn2a2
  • ScpII
  • BFIC3
  • BFIS3
  • BFNIS
  • EIEE11
  • HBA
  • HBSCI
  • HBSCII
  • NAC2
  • Na(v)1.2
  • SCN2A1
  • sodium voltage-gated channel alpha subunit 2
  • sodium channel protein type 2 subunit alpha
  • sodium channel, voltage-gated, type II, alpha
  • sodium channel, voltage-gated, type II, alpha subunit
  • SCN2A
  • LOC100217927
  • LOC100389294
  • LOC100484218
  • Scn2a
  • LOC478773
Reactivité
Mammifères
41
37
24
1
Hôte
Souris
37
9
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp SCN2A est non-conjugé
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunostaining (ISt), Immunohistochemistry (IHC), Western Blotting (WB)
18
13
12
12
8
1
1
1
1
1
Options
Clone K69-3
Isotype IgG2a
Attributs du produit Na+ channels
Purification TC Supernatant: Hybridoma tissue-culture supernatant (5mL) containing 20-40 µg/mL monoclonal antibody (mAb).
Plasmids, Primers & others Plasmids, Primers & others SCN2A products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Nav1.2 (SCN2A Antibody Extrait)
UniProt P04775
Restrictions For Research Use only
Format Liquid
Produit citée dans: Gazina, Leaw, Richards, Wimmer, Kim, Aumann, Featherby, Churilov, Hammond, Reid, Petrou: "'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour." dans: Human molecular genetics, Vol. 24, Issue 5, pp. 1457-68, 2015 (PubMed).

Wildburger, Ali, Hsu, Shavkunov, Nenov, Lichti, LeDuc, Mostovenko, Panova-Elektronova, Emmett, Nilsson, Laezza: "Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain." dans: Molecular & cellular proteomics : MCP, Vol. 14, Issue 5, pp. 1288-300, 2015 (PubMed).

Hamada, Kole: "Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 18, pp. 7272-86, 2015 (PubMed).

Wimmer, Harty, Richards, Phillips, Miyazaki, Nukina, Petrou: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." dans: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, 2015 (PubMed).

Liu, Deng, Wang, Zhang, Luo, Yan, Su, Liu: "KCNE2 modulates cardiac L-type Ca(2+) channel." dans: Journal of molecular and cellular cardiology, Vol. 72, pp. 208-18, 2014 (PubMed).

Baek, Rubinstein, Scheuer, Trimmer: "Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures." dans: The Journal of biological chemistry, Vol. 289, Issue 22, pp. 15363-73, 2014 (PubMed).

Wang, Hooks, Sun: "Thorough GABAergic innervation of the entire axon initial segment revealed by an optogenetic 'laserspritzer'." dans: The Journal of physiology, Vol. 592, Issue Pt 19, pp. 4257-76, 2014 (PubMed).

Li, Tian, Scalmani, Frassoni, Mantegazza, Wang, Yang, Wu, Shu: "Action potential initiation in neocortical inhibitory interneurons." dans: PLoS biology, Vol. 12, Issue 9, pp. e1001944, 2014 (PubMed).

Tian, Wang, Ke, Guo, Shu: "Molecular identity of axonal sodium channels in human cortical pyramidal cells." dans: Frontiers in cellular neuroscience, Vol. 8, pp. 297, 2014 (PubMed).

Martínez-Hernández, Ballesteros-Merino, Fernández-Alacid, Nicolau, Aguado, Luján: "Polarised localisation of the voltage-gated sodium channel Na(v)1.2 in cerebellar granule cells." dans: Cerebellum (London, England), Vol. 12, Issue 1, pp. 16-26, 2013 (PubMed).

He, Liu, Fang, Zhan, Yao, Mei: "Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway." dans: PLoS ONE, Vol. 8, Issue 1, pp. e54376, 2013 (PubMed).

Vega, Avila, Matthews: "Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression." dans: Scientific reports, Vol. 3, pp. 2809, 2013 (PubMed).

Wykes, Kalmbach, Eliava, Waters: "Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice." dans: Neurobiology of aging, Vol. 33, Issue 8, pp. 1609-23, 2012 (PubMed).

Huang, Chu, Hwang, Tsaur: "Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain." dans: The Journal of comparative neurology, Vol. 520, Issue 16, pp. 3650-72, 2012 (PubMed).

Dhaunchak, Becker, Schulman, De Faria, Rajasekharan, Banwell, Colman, Bar-Or: "Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis." dans: Annals of neurology, Vol. 71, Issue 5, pp. 601-13, 2012 (PubMed).

Ahn, Black, Zhao, Tyrrell, Waxman, Dib-Hajj: "Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons." dans: Molecular pain, Vol. 7, pp. 32, 2011 (PubMed).

Lysakowski, Gaboyard-Niay, Calin-Jageman, Chatlani, Price, Eatock: "Molecular microdomains in a sensory terminal, the vestibular calyx ending." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 27, pp. 10101-14, 2011 (PubMed).

Kaphzan, Buffington, Jung, Rasband, Klann: "Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 48, pp. 17637-48, 2011 (PubMed).

Kress, Dowling, Eisenman, Mennerick: "Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons." dans: Hippocampus, Vol. 20, Issue 4, pp. 558-71, 2010 (PubMed).

Merrick, Kalmar, Snyder, Cusdin, Yu, Sando, Isakson, Jackson, Patel: "The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating." dans: Pflügers Archiv : European journal of physiology, Vol. 460, Issue 4, pp. 743-53, 2010 (PubMed).

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