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FOXO3 anticorps (pSer253)

FOXO3 Reactivité: Humain, Souris, Rat WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1355836
  • Antigène Voir toutes FOXO3 Anticorps
    FOXO3 (Forkhead Box O3 (FOXO3))
    Épitope
    • 30
    • 16
    • 13
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer253
    Reactivité
    • 176
    • 130
    • 121
    • 9
    • 8
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 172
    • 5
    • 1
    • 1
    Lapin
    Clonalité
    • 162
    • 17
    Polyclonal
    Conjugué
    • 71
    • 15
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp FOXO3 est non-conjugé
    Application
    • 113
    • 61
    • 52
    • 35
    • 28
    • 27
    • 14
    • 14
    • 14
    • 14
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Specificité
    The antibody detects endogenous level of FKHRL1 only when phosphorylated at serine 253.
    Immunogène
    Peptide sequence around phosphorylation site of pSer253 (A-V-S (p) -M-D) derived from Human FKHRL1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Top Product
    Discover our top product FOXO3 Anticorps primaire
  • Indications d'application
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Immunofluorescence: 1:100-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C
  • Pierce, Podlutskaya, Halloran, Hussong, Lin, Burbank, Hart, Galvan: "Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease." dans: Journal of neurochemistry, Vol. 124, Issue 6, pp. 880-93, (2013) (PubMed).

    Zhan, Wang, Li, Xu, Sun, Xu: "Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats." dans: Journal of neurochemistry, Vol. 114, Issue 3, pp. 897-908, (2010) (PubMed).

  • Antigène
    FOXO3 (Forkhead Box O3 (FOXO3))
    Autre désignation
    FKHRL1 (FOXO3 Produits)
    Synonymes
    anticorps AF6q21, anticorps FKHRL1, anticorps FKHRL1P2, anticorps FOXO2, anticorps FOXO3A, anticorps zgc:92176, anticorps wu:fb50g02, anticorps wu:fi33f07, anticorps Fkhrl1, anticorps Foxo3a, anticorps FoxO3A, anticorps 1110048B16Rik, anticorps 2010203A17Rik, anticorps C76856, anticorps Fkhr2, anticorps FOXO-3, anticorps FOXO3, anticorps foxo3a, anticorps xfoxo3, anticorps foxO3, anticorps foxO, anticorps fkhr, anticorps foxo5, anticorps wu:fj65a12, anticorps zFkhr, anticorps forkhead box O3, anticorps forkhead box O3A, anticorps forkhead box O3 L homeolog, anticorps forkhead box O3b, anticorps FOXO3, anticorps foxo3a, anticorps Foxo3, anticorps foxo3.L, anticorps foxo3, anticorps foxO3, anticorps foxo3b
    Sujet
     Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
    Poids moléculaire
    97 kDa
    NCBI Accession
    NP_001446, NM_001455
    UniProt
    O43524
    Pathways
    Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
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