CD130/gp130 anticorps

N° du produit ABIN1383681

Détail du produit anti-CD130/gp130 anticorps

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD130/gp130 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificité: Recognises Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein

Purification: Ion exchange chromatography

Stérilité: 0.22 μm filtered

Immunogène: Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells

Clone: B-K5

Isotype: IgG1 kappa

Biological Activity Comment: Inhibits CNTF activity. Inhibits OSM binding to gp130

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Agent conservateur: Without preservative

Stock: 4 °C

Stockage commentaire: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Références pour anticorps anti-CD130/gp130 (ABIN1383681)

Durda, Dunn, Rose, Butera, Benson, Pandolfi, Kurnick: "Induction of \" in melanomas by oncostatin M: down-modulation of melanocyte antigen expression." dans: Molecular cancer research : MCR, Vol. 1, Issue 6, pp. 411-9, (2003) (PubMed).

Auguste, Guillet, Fourcin, Olivier, Veziers, Pouplard-Barthelaix, Gascan: "Signaling of type II oncostatin M receptor." dans: The Journal of biological chemistry, Vol. 272, Issue 25, pp. 15760-4, (1997) (PubMed).

Gu, Wijdenes, Zhang, Hallet, Clement, Klein: "Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M." dans: Journal of immunological methods, Vol. 190, Issue 1, pp. 21-7, (1996) (PubMed).

Chevalier, Fourcin, Robledo, Wijdenes, Pouplard-Barthelaix, Gascan: "Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein." dans: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14764-72, (1996) (PubMed).

Baumann, Morella, White, Dembski, Bailon, Kim, Lai, Tartaglia: "The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 16, pp. 8374-8, (1996) (PubMed).

Détails sur CD130/gp130

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Autre désignation: CD130 (IL6ST Produits)

Synonymes: anticorps CD130, anticorps CDW130, anticorps GP130, anticorps IL-6RB, anticorps 5133400A03Rik, anticorps AA389424, anticorps BB405851, anticorps D13Ertd699e, anticorps gp130, anticorps Ac1055, anticorps Gp130, anticorps Il-6rb, anticorps IL-6, anticorps interleukin 6 signal transducer, anticorps IL6ST, anticorps Il6st, anticorps il6st

Sujet: Gp130

Poids moléculaire: 130-140 kDa

Pathways: Signalistation JAK/STAT, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints