APBA1 anticorps (AA 451-550)

N° du produit ABIN1386516

Détail du produit anti-APBA1 anticorps

Antigène: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Épitope: AA 451-550

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APBA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human APBA1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur APBA1

Antigène: APBA1 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 1 (APBA1))

Autre désignation: APBA1 (APBA1 Produits)

Synonymes: anticorps APBA1, anticorps 6430513E09Rik, anticorps Lin-10, anticorps Mint, anticorps Mint1, anticorps Urop11, anticorps X11, anticorps X11alpha, anticorps D9S411E, anticorps LIN10, anticorps MINT1, anticorps X11A, anticorps X11ALPHA, anticorps amyloid beta precursor protein binding family A member 1, anticorps amyloid beta (A4) precursor protein-binding, family A, member 1b, anticorps ketopantoate reductase, anticorps 2-dehydropantoate 2-reductase, anticorps amyloid beta (A4) precursor protein-binding, family A, member 1 (X11), anticorps amyloid beta (A4) precursor protein-binding, family A, member 1, anticorps amyloid beta (A4) precursor protein binding, family A, member 1, anticorps APBA1, anticorps apba1b, anticorps apbA1, anticorps apba1, anticorps Apba1

Sujet:

Synonyms: Adapter protein X11 alpha; Adapter protein X11alpha; Amyloid beta A4 precursor protein-binding family A member 1; Apba1; APBA1_HUMAN; Mint 1; Mint-1; Neuron specic X11 protein; Neuron-specic X11 protein; Neuronal Munc18 1 interacting protein 1; Neuronal Munc18-1-interacting protein 1; UROP11; x11; X11alpha.

Background: The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer?s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the -Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport