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DEPTOR anticorps (AA 56-170)

DEPTOR Reactivité: Humain, Souris, Rat WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1387597
  • Antigène Voir toutes DEPTOR Anticorps
    DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))
    Épitope
    • 15
    • 14
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 56-170
    Reactivité
    • 46
    • 33
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 41
    • 4
    • 1
    Lapin
    Clonalité
    • 44
    • 2
    Polyclonal
    Conjugué
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp DEPTOR est non-conjugé
    Application
    • 44
    • 25
    • 25
    • 9
    • 7
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Dog,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DEPTOR/DEPDC6
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Liu, Cai, Zhang, Liu, Luo, Xing, Du: "Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress." dans: Nucleic acids research, Vol. 46, Issue 18, pp. 9601-9616, (2019) (PubMed).

    Liu, Zhang, Liu, Li, Zhang, Li, Liu, Huang, Shen, Gu, Gao, Wu, Wu: "High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma." dans: OncoTargets and therapy, Vol. 8, pp. 3449-55, (2015) (PubMed).

  • Antigène
    DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))
    Autre désignation
    Deptor (DEPTOR Produits)
    Synonymes
    anticorps DEP.6, anticorps DEPDC6, anticorps 4731402B04Rik, anticorps 9130412E02Rik, anticorps D15Ertd336e, anticorps D15Ertd597e, anticorps Depdc6, anticorps Depdc6-001, anticorps Depdc6-002, anticorps R75183, anticorps mKIAA4200, anticorps RGD1561030, anticorps RAPGEF4, anticorps DEP domain containing MTOR interacting protein, anticorps DEP domain containing MTOR-interacting protein, anticorps DEPTOR, anticorps Deptor
    Sujet

    Synonyms: DEP.6, DEPDC6, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6, DEPTOR

    Background: DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

    ID gène
    64798
    UniProt
    Q8TB45
    Pathways
    Signalisation PI3K-Akt, Signalisation RTK, Regulation of Cell Size, BCR Signaling, L'effet Warburg
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