UBE2D3 anticorps (AA 55-147)
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- Antigène Voir toutes UBE2D3 Anticorps
- UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))
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Épitope
- AA 55-147
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp UBE2D3 est non-conjugé
- Application
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Souris
- Homologie
- Human,Rat,Cow,Pig,Horse,Chicken,Rabbit,Zebrafish
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human UBE2D3
- Isotype
- IgG
- Top Product
- Discover our top product UBE2D3 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))
- Autre désignation
- UBE2D3 (UBE2D3 Produits)
- Synonymes
- anticorps E2(17)KB3, anticorps UBC4/5, anticorps UBCH5C, anticorps eff, anticorps fb36f02, anticorps wu:fb36f02, anticorps zgc:56340, anticorps 1100001F19Rik, anticorps 9430029A22Rik, anticorps AA414951, anticorps UBE2D3P, anticorps Xubc4, anticorps e2(17)kb3, anticorps ubc4/5, anticorps ubch5c, anticorps ube2d3.1, anticorps ube2d2, anticorps xubc4, anticorps wu:fj13d01, anticorps zgc:73200, anticorps ubiquitin conjugating enzyme E2 D3, anticorps ubiquitin-conjugating enzyme E2D 3, anticorps ubiquitin conjugating enzyme E2 D3 L homeolog, anticorps ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like, anticorps UBE2D3, anticorps ube2d3, anticorps Ube2d3, anticorps LOC100223566, anticorps ube2d3.L, anticorps ube2d2l
- Sujet
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Synonyms: E217KB3, MGC43926, MGC5416, UB2D3_HUMAN, UBC 4/5, UBC4/5, UBC4/5 homolog yeast, UBCH 5C, UBCH5C, Ube2d3, Ubiquitin carrier protein, Ubiquitin carrier protein D3, Ubiquitin conjugating enzyme E2 17 kDa 3, Ubiquitin conjugating enzyme E2 D3, Ubiquitin conjugating enzyme E2D 3 homologous to yeast UBC4/5, Ubiquitin conjugating enzyme E2D 3 UBC4/5 homolog yeast, Ubiquitin conjugating enzyme E2D 3, Ubiquitin protein ligase D3, Ubiquitin-conjugating enzyme E2 D3, Ubiquitin-conjugating enzyme E217KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-protein ligase D3.
Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.
- ID gène
- 7323
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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