C1QC anticorps (AA 81-180) (Alexa Fluor 350)

N° du produit ABIN1390671

Détail du produit anti-C1QC anticorps (Alexa Fluor 350)

Antigène: C1QC (Complement Component 1, Q Subcomponent, C Chain (C1QC))

Épitope: AA 81-180

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C1QC est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human C1QC

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur C1QC

Antigène: C1QC (Complement Component 1, Q Subcomponent, C Chain (C1QC))

Autre désignation: C1QC/C1QG (C1QC Produits)

Synonymes: anticorps c1qc, anticorps AI385742, anticorps C1qg, anticorps Ciqc, anticorps C1Q-C, anticorps C1QG, anticorps complement C1q C chain, anticorps complement component 1, q subcomponent, C chain, anticorps C1QC, anticorps c1qc, anticorps C1qc

Sujet:

Synonyms: C1Q C, C1qc, C1QC_HUMAN, C1QG, Complement C1q subcomponent subunit C, Complement component 1, q subcomponent, C chain, complement component 1, q subcomponent, gamma polypeptide, AI385742.

Background: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA, as well as the protein. However, its ability to modulate the interaction of platelets with collagen and immune complexes suggests C1q influences homeostasis as well as other immune activities, and perhaps thrombotic complications resulting from immune injury. Defects in C1q-A, C1q-B and C1q-C cause inactivation of the classical pathway, leading to a rare genetic disorder characterized by lupus-like symptoms.

Pathways: Système du Complément