GNRHR2 anticorps (AA 81-180) (Biotin)

N° du produit ABIN1391071

Détail du produit anti-GNRHR2 anticorps (Biotin)

Antigène: GNRHR2 (Gonadotropin-Releasing Hormone (Type 2) Receptor 2 (GNRHR2))

Épitope: AA 81-180

Reactivité: Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GNRHR2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Porc

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GNRHR2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur GNRHR2

Antigène: GNRHR2 (Gonadotropin-Releasing Hormone (Type 2) Receptor 2 (GNRHR2))

Autre désignation: GNRHR2 (GNRHR2 Produits)

Synonymes: anticorps gnrhr1/iii, anticorps GnRH-II-R, anticorps gonadotropin releasing hormone receptor 2 (pseudogene), anticorps gonadotropin-releasing hormone (type 2) receptor 2, anticorps gnrhr2, anticorps GNRHR2

Sujet:

Synonyms: GnRH IIR, Putative gonadotropin-releasing hormone II receptor, gonadotropin-releasing hormone type 2 receptor 2, GnRH-II-R, Type II GnRH receptor, GNRR2_HUMAN.

Background: Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms.